Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.50 |
| ▸ | FLT3 | P36888 | 8/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | STK17B | O94768 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27403085 | 1.00 | CHEK1 (0.50) | CHEK1FLT3TBK1KITPOLB | |
| SCHEMBL27087891 | 0.86 | TBK1 (0.51) | CHEK1FLT3TBK1KITSTK17A | |
| SCHEMBL1916143 | 0.85 | STK17A (0.56) | CHEK1FLT3KITSTK17ASTK17B | |
| SCHEMBL3284584 | 0.84 | STK17A (0.55) | CHEK1FLT3KITSTK17ASTK17B | |
| SCHEMBL27087858 | 0.80 | CHEK1 (0.63) | CHEK1FLT3KIT | |
| SCHEMBL29989296 | 0.80 | CHEK1 (0.63) | CHEK1FLT3KIT | |
| SCHEMBL1917119 | 0.79 | ULK1 (0.48) | CHEK1FLT3TBK1KITSTK17A | |
| SCHEMBL1918823 | 0.79 | CHEK1 (0.49) | CHEK1FLT3TBK1KITSTK17A | |
| SCHEMBL1916130 | 0.78 | STK17A (0.53) | CHEK1FLT3KITSTK17ASTK17B | |
| SCHEMBL3284402 | 0.78 | STK17A (0.52) | CHEK1FLT3KITSTK17ASTK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320121-A2 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES AS ULK1/2 INHIBITORS AND THEIR USE THEREOF | LifeArc (GB) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022214869-A2 | ULK1/2 INHIBITORS AND THEIR USE THEREOF | LIFEARC (GB) | 2022-10-13 | — | — | WO | disclosed |