SCHEMBL29990463

SCHEMBL29990463

CC(C)(C)OC(=O)N1CCN(CC2CCN(c3ccc(-c4ccc(OCc5ccccc5)nc4OCc4ccccc4)cc3)CC2)CC1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 6/20 0.47
ALK Q9UM73 1/20 0.46
PRMT5 O14744 4/20 0.43
CCNT1 O60563 1/20 0.42
CCNA2 P20248 1/20 0.42
CDK2 P24941 1/20 0.42
CDK9 P50750 1/20 0.42
CCNA1 P78396 1/20 0.42
YAP1 P46937 2/20 0.41
DDB1 Q16531 1/20 0.40
CRBN Q96SW2 1/20 0.40
ACHE P22303 1/20 0.40
JAK2 O60674 1/20 0.40
JAK3 P52333 1/20 0.40
TLR9 Q9NR96 1/20 0.40
TLR7 Q9NYK1 1/20 0.40
KIT P10721 1/20 0.40
FLT3 P36888 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24670637 1.00 GPR119 (0.47) GPR119ALKPRMT5CCNT1CCNA2
SCHEMBL29990523 0.97 GPR119 (0.47) GPR119ALKPRMT5YAP1DDB1
SCHEMBL24670554 0.97 GPR119 (0.47) GPR119ALKPRMT5YAP1DDB1
SCHEMBL30981436 0.92 VCP (0.46) GPR119ALKPRMT5CCNT1CCNA2
SCHEMBL24671173 0.91 GPR119 (0.50) GPR119ALKPRMT5CCNT1CCNA2
SCHEMBL29991095 0.91 GPR119 (0.50) GPR119ALKPRMT5CCNT1CCNA2
SCHEMBL23301621 0.90 GPR119 (0.54) GPR119ALKACHEJAK2JAK3
SCHEMBL26641345 0.89 GPR119 (0.47) GPR119ALKPRMT5CCNT1CCNA2
SCHEMBL31342432 0.89 YAP1 (0.44) GPR119ALKPRMT5YAP1JAK2
SCHEMBL31342391 0.89 YAP1 (0.44) GPR119ALKPRMT5YAP1JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4334302-A1 COMPOUNDS FOR INHIBITING OR DEGRADING TARGET PROTEINS, COMPOSITIONS, COMPRISING THE SAME, METHODS OF THEIR MAKING, AND METHODS OF THEIR USE Nurix Therapeutics, Inc. (US) 2024-03-13 EP disclosed
EP-4334303-A1 COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE Nurix Therapeutics, Inc. (US) 2024-03-13 EP disclosed
WO-2022235715-A1 COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE NURIX THERAPEUTICS, INC. (US) 2022-11-10 WO disclosed
WO-2022235698-A1 COMPOUNDS FOR INHIBITING OR DEGRADING TARGET PROTEINS, COMPOSITIONS, COMPRISING THE SAME, METHODS OF THEIR MAKING, AND METHODS OF THEIR USE NURIX THERAPEUTICS, INC. (US) 2022-11-10 WO disclosed