Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.79 |
| ▸ | RB1 | P06400 | 7/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTR5A | P47898 | 1/20 | 0.51 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD5 | P21918 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29991655 | 1.00 | NR2E1 (0.79) | NR2E1RB1HTR2AHTR2CKDM4E | |
| SCHEMBL6533665 | 1.00 | NR2E1 (0.79) | NR2E1RB1HTR2AHTR2CKDM4E | |
| SCHEMBL4905673 | 1.00 | NR2E1 (0.79) | NR2E1RB1HTR2AHTR2CKDM4E | |
| Hydrochloric Acid SCHEMBL11283863 | 0.98 | NR2E1 (0.77) | NR2E1RB1HTR2AHTR2CKDM4E | |
| SCHEMBL700531 | 0.88 | NR2E1 (1.00) | NR2E1RB1HTR2AHTR2CHTR6 | |
| SCHEMBL834930 | 0.88 | NR2E1 (1.00) | NR2E1RB1HTR2AHTR2CHTR6 | |
| SCHEMBL29670383 | 0.88 | NR2E1 (1.00) | NR2E1RB1HTR2AHTR2CHTR6 | |
| SCHEMBL833503 | 0.88 | NR2E1 (1.00) | NR2E1RB1HTR2AHTR2CHTR6 | |
| Hydrochloric Acid SCHEMBL7412638 | 0.87 | NR2E1 (0.97) | NR2E1RB1HTR2AHTR2CHTR6 | |
| SCHEMBL21754369 | 0.84 | NR2E1 (0.75) | NR2E1RB1HTR2AHTR2CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | CYTOKINETICS INC (US) | 2022-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | TNNT2, TNNI3, MYLK2 | NR2E1 3383/4885RB1 3803/4885HTR2A 2280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.