Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2E1 | Q9Y466 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 4/20 | 0.59 |
| ▸ | HTR1D | P28221 | 3/20 | 0.59 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | RB1 | P06400 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL700531 | 1.00 | NR2E1 (1.00) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL833503 | 1.00 | NR2E1 (1.00) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL29670383 | 1.00 | NR2E1 (1.00) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| Hydrochloric Acid SCHEMBL7412638 | 0.98 | NR2E1 (0.97) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL29991655 | 0.88 | NR2E1 (0.79) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL29992005 | 0.88 | NR2E1 (0.79) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL6533665 | 0.88 | NR2E1 (0.79) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL4905673 | 0.88 | NR2E1 (0.79) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| Hydrochloric Acid SCHEMBL11283863 | 0.87 | NR2E1 (0.77) | NR2E1HTR6HTR1BHTR1DHTR2A | |
| SCHEMBL8702813 | 0.87 | NR2E1 (0.75) | NR2E1HTR6HTR1BHTR1DHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220144839-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2022-05-12 | — | — | US | disclosed |
| CN-113272305-A | Indole AHR inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2021-08-17 | — | — | CN | disclosed |
| CN-104402798-B | A kind of 3-amino-1, the method for splitting of 2,3,4-tetrahydro carbazoles | 杭州瑞德化工有限公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-104402798-A | Resolution method for 3-amino-1, 2, 3, 4-tetrahydrocarbazole | HANGZHOU READ CHEMICAL CO LTD | 2015-03-11 | — | — | CN | disclosed |
| US-8143304-B2 | (3-amino-1,2,3,4-tetrahydro-9 H-carbazol-9-yl)-acetic acid derivatives | ACTELION PHARMACEUTICAL LTD. (CH) | 2012-03-27 | — | — | US | disclosed |
| EP-2051962-B1 | (3-AMINO-1,2,3,4-TETRAHYDRO-9H-CARBAZOL-9-YL)-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2316824-A1 | (3-Amino-1,2,3,4-tetrahydro-9H-carbazoI-9-yl)-acetic acid derivates | Actelion Pharmaceuticals Ltd. (CH) | 2011-05-04 | — | — | EP | disclosed |
| US-20100190830-A1 | (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144839-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | NR2E1 391/4885HTR6 39/4885HTR1B 76/4885 |
| US-20100190830-A1 | (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives | PTGDR, PTGER1, PTGIR | NR2E1 723/4885HTR6 219/4885HTR1B 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.