Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.44 |
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29992609 | 0.83 | NOS3 (0.49) | NOS3NOS2MAPK1ADRB1CHRNB2 | |
| SCHEMBL2338512 | 0.82 | NOS3 (0.50) | NOS3NOS2MAPK1ADRB1MAP3K12 | |
| SCHEMBL28284245 | 0.79 | NOS3 (0.47) | NOS3NOS2MAPK1ADRB1MAP3K12 | |
| SCHEMBL3782541 | 0.78 | CHRNB2 (0.51) | NOS3NOS2MAPK1ADRB1CHRNB2 | |
| SCHEMBL31061341 | 0.78 | CHRNB2 (0.51) | NOS3NOS2MAPK1ADRB1CHRNB2 | |
| SCHEMBL28282678 | 0.78 | NOS3 (0.46) | NOS3NOS2MAPK1ADRB1MAP3K12 | |
| SCHEMBL29991850 | 0.77 | MAP3K12 (0.37) | NOS3NOS2MAPK1ADRB1MAP3K12 | |
| SCHEMBL29992344 | 0.77 | NOS3 (0.44) | NOS3NOS2MAPK1ADRB1MAP3K12 | |
| SCHEMBL29991973 | 0.76 | NOS3 (0.38) | NOS3NOS2MAPK1ADRB1CHRNB2 | |
| SCHEMBL7074219 | 0.75 | MAPK1 (0.58) | NOS3NOS2MAPK1ADRB1MAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | CYTOKINETICS INC (US) | 2022-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220332708-A1 | SULFONAMIDE COMPOUNDS AS CARDIAC SARCOMERE ACTIVATORS | TNNT2, TNNI3, MYLK2 | NOS3 2789/4885NOS2 2448/4885MAPK1 2425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.