Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.65 |
| ▸ | CDC42 | P60953 | 1/20 | 0.65 |
| ▸ | RAC1 | P63000 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134150 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL1448280 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL29993492 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL554068 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL13810650 | 0.89 | AKR1C3 (0.53) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL12744140 | 0.88 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL11470486 | 0.85 | AKR1C3 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL10025981 | 0.83 | AKR1B1 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL1217681 | 0.83 | AKR1B1 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| Ammonia Solution, Strong SCHEMBL11721423 | 0.83 | AKR1C3 (0.67) | AKR1C3AKR1C2PTGS2PTGS1CDC42 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | claimed |
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | claimed |
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | disclosed |
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | disclosed |