Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 13/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 13/20 | 0.65 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.65 |
| ▸ | CDC42 | P60953 | 1/20 | 0.65 |
| ▸ | RAC1 | P63000 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL134150 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL29993492 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL554068 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL29993475 | 1.00 | AKR1C3 (0.65) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL13810650 | 0.89 | AKR1C3 (0.53) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL12744140 | 0.88 | AKR1C3 (0.51) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL11470486 | 0.85 | AKR1C3 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL10025981 | 0.83 | AKR1B1 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| SCHEMBL1217681 | 0.83 | AKR1B1 (0.69) | AKR1C3AKR1C2PTGS2PTGS1CDC42 | |
| Ammonia Solution, Strong SCHEMBL11721423 | 0.83 | AKR1C3 (0.67) | AKR1C3AKR1C2PTGS2PTGS1CDC42 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | claimed |
| CN-115322099-A | Naproxen-cinnamic acid derivatives and application thereof in preparation of drugs for treating LPS (LPS) -induced inflammation | 五邑大学 | 2022-11-11 | — | — | CN | claimed |
| US-6740256-B1 | COMPOSED OF THE COMPOUND OF (N,N'-DIETHYL (S)-2-(6-(4-(4'-ALKOXYPHENYL)BENZOYLOXY)-2-NAPHTHYL)PROPANAMIDE | CHUNGHWA PICTURE TUBES, LTD. (TW) | 2004-05-25 | — | — | US | claimed |
| JP-2053819-A | — | — | None | — | — | JP | disclosed |
| JP-3031393-A | — | — | None | — | — | JP | disclosed |
| EP-3160514-B1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | REILEY PHARMACEUTICALS INC (US) | 2024-07-31 | — | — | EP | disclosed |
| US-20240190790-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | REILEY PHARMACEUTICALS INC (US) | 2024-06-13 | — | — | US | disclosed |
| CN-115322099-B | Naproxen-cinnamic acid derivative and application thereof in preparation of medicines for treating LPS-induced inflammation | 五邑大学 | 2024-04-02 | — | — | CN | disclosed |
| US-11912664-B2 | Determining small molecule-protein and protein-protein interactions | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2024-02-27 | — | — | US | disclosed |
| EP-3892610-B1 | SULFUR (VI) FLUORIDE COMPOUNDS AND THEIR USE IN CLICK-REACTION | SCRIPPS RESEARCH INST (US) | 2023-08-16 | — | — | EP | disclosed |
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | UNIV PENNSYLVANIA (US) | 2023-02-09 | — | — | US | disclosed |
| JP-H0331393-A | LIQUID CRYSTAL POLYMER COMPOSITION CONTAINING OPTICAL ACTIVE GROUP | TOSOH CORP | 1991-02-12 | — | — | JP | disclosed |
| US-4960892-A | ENZYME INHIBITOR | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0301813-B1 | NAPHTHALENEPROPIONIC ACID DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-08-08 | — | — | EP | disclosed |
| US-4937373-A | Substituted naphthalene carboxylic acids | HOFFMANN-LA ROCHE INC. (US) | 1990-06-26 | — | — | US | disclosed |
| JP-H0253819-A | LIQUID CRYSTALLINE POLYESTER CONTAINING OPTICALLY ACTIVE GROUP | TOSOH CORP | 1990-02-22 | — | — | JP | disclosed |
| EP-0301813-A1 | Naphthalenepropionic acid derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-02-01 | — | — | EP | disclosed |
| EP-0227078-A1 | Process for preparing (S)-alpha-methylarylacetic acids | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1987-07-01 | — | — | EP | disclosed |
| EP-0110671-B1 | PREPARATION OF OPTICALLY ACTIVE ALPHA-ARYLALKANOIC ACIDS AND PRECURSORS THEREOF | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1986-05-21 | — | — | EP | disclosed |
| EP-0110671-A1 | Preparation of optically active alpha-arylalkanoic acids and precursors thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1984-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230039244-A1 | 2-BETA-NAPHTHYL-ACETIC ACID ANALOGS AS AKR1C3 INHIBITORS AND METHODS OF USING SAME | AKR1C3, AKR1C2, AKR1A1 | AKR1C3 1/4885AKR1C2 2/4885PTGS2 261/4885 |
| US-20240190790-A1 | CONJUGATES DERIVED FROM NON-STEROIDAL ANTI-INFLAMMATORY DRUGS AND METHODS OF USE THEREOF IN IMAGING | PTGES3, PTGES, HPGDS | AKR1C3 568/4885AKR1C2 1264/4885PTGS2 6/4885 |
| US-11912664-B2 | Determining small molecule-protein and protein-protein interactions | MAX, IK, CRYAA | AKR1C3 4555/4885AKR1C2 4503/4885PTGS2 2854/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.