SCHEMBL2999428

SCHEMBL2999428

O=C1C=CC(=O)N1c1ccc(C(F)(F)F)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 13/20 0.65
FAAH O00519 5/20 0.65
HSP90AA1 P07900 4/20 0.54
PKM P14618 2/20 0.54
TDP1 Q9NUW8 2/20 0.54
BCHE P06276 1/20 0.54
MAPK1 P28482 1/20 0.54
NPSR1 Q6W5P4 1/20 0.54
ALDH1A1 P00352 2/20 0.48
LMNA P02545 2/20 0.48
CCR6 P51684 2/20 0.48
MEN1 O00255 1/20 0.48
HPGD P15428 1/20 0.48
HTT P42858 1/20 0.48
KMT2A Q03164 1/20 0.48
ATM Q13315 1/20 0.48
DDAH1 O94760 1/20 0.48
CACNA1B Q00975 1/20 0.47
APBA1 Q02410 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1155772 0.83 MGLL (0.60) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL95324 0.81 MGLL (1.00) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL10297377 0.80 MGLL (0.56) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL8856016 0.80 MGLL (0.68) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL11937129 0.80 PRSS1 (0.54) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL8730226 0.78 CCR6 (0.48) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL2412811 0.78 MGLL (0.65) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL3185260 0.78 MGLL (0.65) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL9588255 0.78 MGLL (0.65) MGLLFAAHHSP90AA1PKMTDP1
SCHEMBL31179960 0.77 MGLL (0.58) MGLLFAAHHSP90AA1PKMTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115948751-B Method for electrocatalytic ring-opening dihydro-alkoxylation reaction of N-aryl maleimide and alcohol 广西师范大学 2024-10-01 CN claimed
CN-118126241-A Tetrapolymer, high-temperature-resistant flame-retardant ABS and preparation method thereof 四川轻化工大学 2024-06-04 CN claimed
EP-1051665-B1 PHOTOPOLYMERIZATION COMPOSITIONS INCLUDING MALEIMIDES AND PROCESSES FOR USING THE SAME ALBEMARLE CORP (US) 2006-07-12 EP claimed
US-6555593-B1 Maleimides with a benzophenone compound/hydrogen atom donor sensitizer system activated by irradiation ALBEMARLE CORPORATION 2003-04-29 US claimed
CN-1295680-A Photopolymerization compositions including maleimides and processes for using the same FIRST CHEMICAL CORP (US) 2001-05-16 CN claimed
EP-1051665-A1 PHOTOPOLYMERIZATION COMPOSITIONS INCLUDING MALEIMIDES AND PROCESSES FOR USING THE SAME First Chemical Corporation (US) 2000-11-15 EP claimed
WO-1999039247-A1 PHOTOPOLYMERIZATION COMPOSITIONS INCLUDING MALEIMIDES AND PROCESSES FOR USING THE SAME FIRST CHEMICAL CORPORATION (US) 1999-08-05 WO claimed
CN-115948751-B Method for electrocatalytic ring-opening dihydro-alkoxylation reaction of N-aryl maleimide and alcohol 广西师范大学 2024-10-01 CN disclosed
CN-118126241-A Tetrapolymer, high-temperature-resistant flame-retardant ABS and preparation method thereof 四川轻化工大学 2024-06-04 CN disclosed
CN-114432301-B Covalent inhibitor derivative and application thereof in treatment of viral infection 北京大学 2024-05-31 CN disclosed
CN-115948751-A Ring-opening dihydroalkoxylation reaction method of electrocatalytic N-aryl maleimide and alcohol 广西师范大学 2023-04-11 CN disclosed
CN-114432301-A Covalent inhibitor derivative and application thereof in treating virus infection 北京大学 2022-05-06 CN disclosed
US-20220064195-A1 SYNTHETIC I2 IMIDAZOLINE RECEPTOR LIGANDS FOR PREVENTION OR TREATMENT OF HUMAN BRAIN DISORDERS UNIVERSITAT DE LES ILLES BALEARS (ES) 2022-03-03 US disclosed
US-5587445-A Highly oxygen-permeable heat-resistant material MENICON CO., LTD. (JP) 1996-12-24 US disclosed
EP-0734526-A1 MALEIMIDE ADDUCT CONJUGATES OF PROCAINAMIDE AND NAPA BOEHRINGER MANNHEIM CORPORATION (US) 1996-10-02 EP disclosed
EP-0722959-A2 Highly oxygen-permeable heat-resistant material Menicon Co., Ltd. (JP) 1996-07-24 EP disclosed
WO-1995016894-A1 MALEIMIDE ADDUCT CONJUGATES OF PROCAINAMIDE AND NAPA BOEHRINGER MANNHEIM CORPORATION (US) 1995-06-22 WO disclosed
US-5169923-A High glass transition temperature, heat and oxidation resistance HAY ALLAN S (CA) 1992-12-08 US disclosed
WO-1992020656-A1 BISPHENOLS AND POLY(IMIDOARYLETHER KETONE)S AND POLY(IMIDOARYLETHER SULFONE)S PRODUCED THEREFROM HAY ALLAN S (CA) 1992-11-26 WO disclosed
US-5110934-A Intermediates for polymers having good solubility, high glass transition temperatures and thermo-oxidative stability HAY ALLAN S (CA) 1992-05-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220064195-A1 SYNTHETIC I2 IMIDAZOLINE RECEPTOR LIGANDS FOR PREVENTION OR TREATMENT OF HUMAN BRAIN DISORDERS CHRM1, GPR3, CHRM3 MGLL 3253/4885FAAH 1637/4885HSP90AA1 3670/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.