Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.47 |
| ▸ | TEK | Q02763 | 6/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.38 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.38 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719766 | 0.88 | KDR (0.49) | KDREPHB4TEKALKEGLN1 | |
| SCHEMBL296241 | 0.84 | EGLN1 (0.39) | EGLN1MAPK1GSK3BHDAC8 | |
| SCHEMBL10325548 | 0.82 | NTRK1 (0.40) | KDREPHB4TEKEGLN1CDC7 | |
| SCHEMBL285634 | 0.82 | CCNK (0.42) | EGLN1CDC7GSK3BHDAC8 | |
| SCHEMBL2722435 | 0.77 | KDM4A (0.42) | EGLN1CDC7GSK3BHDAC8 | |
| SCHEMBL3804479 | 0.76 | GSK3B (0.41) | MAPK1GSK3B | |
| SCHEMBL294699 | 0.75 | KDM1A (0.40) | EGLN1 | |
| SCHEMBL10104592 | 0.74 | MET (0.43) | KDREPHB4TEKALKEGLN1 | |
| SCHEMBL286188 | 0.73 | ALK (0.75) | KDREPHB4TEKALK | |
| SCHEMBL721655 | 0.71 | EGLN1 (0.41) | EGLN1MAPK1GSK3BHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427461-B1 | 3-([1,2,3]TRIAZOL-4-YL)-PYRROLO[2,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-10-09 | — | — | EP | disclosed |
| EP-2427461-A1 | 3-(Ý1,2,3¨TRIAZOLE-4-YL)-PYRROLOÝ2,3-B¨PYRIDINE DERIVATES | Merck Patent GmbH (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127754-A1 | 3-([1,2,3]TRIAZOLE-4-YL)-PYRROLO[2,3-B]PYRIDINE DERIVATES | MERCK PATENT GMBH (DE) | 2010-11-11 | — | — | WO | disclosed |