Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL826483 | 0.82 | CA12 (0.53) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| 1,4-Diallyloxybenzene SCHEMBL302448 | 0.79 | CA12 (0.63) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL7929787 | 0.79 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| SCHEMBL14441303 | 0.78 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2POLBMAPTUSP2 | |
| SCHEMBL717219 | 0.77 | NPC1 (0.53) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| SCHEMBL7929785 | 0.76 | CA12 (0.52) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| SCHEMBL7782792 | 0.76 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| SCHEMBL3004004 | 0.76 | NQO1 (0.61) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL12370720 | 0.76 | CA12 (0.47) | ALDH1A1SMN1; SMN2HPGDKDM4EPOLB | |
| SCHEMBL7132909 | 0.76 | LTA4H (0.55) | ALDH1A1SMN1; SMN2POLBFFAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470813-B2 | Thiazoline and oxazoline derivatives and their methods of use | ABBVIE INC. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20100190776-A1 | Thiazoline and Oxazoline Derivatives and Their Methods of Use | ABBOTT LABORATORIES (US) | 2010-07-29 | — | — | US | disclosed |
| US-7683084-B2 | Thiazoline and oxazoline derivatives and their methods of use | ABBOTT LABORATORIES (US) | 2010-03-23 | — | — | US | disclosed |
| CN-101479262-A | Thiazoline and oxazoline derivatives and their methods of use | ABBOTT LAB (US) | 2009-07-08 | — | — | CN | disclosed |
| US-20080070929-A1 | THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE | ABBVIE INC. | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190776-A1 | Thiazoline and Oxazoline Derivatives and Their Methods of Use | OXA1L, CYP3A7, ABAT | ALDH1A1 254/4885SMN1; SMN2 2018/4885HPGD 966/4885 |
| US-20080070929-A1 | THIAZOLINE AND OXAZOLINE DERIVATIVES AND THEIR METHODS OF USE | OXA1L, CYP3A7, ABAT | ALDH1A1 254/4885SMN1; SMN2 2018/4885HPGD 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.