Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.49 |
| ▸ | SCN4A | P35499 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828076 | 0.88 | ALDH1A1 (0.46) | SCN8AALDH1A1KDM4ETDP1CYP1A2 | |
| SCHEMBL29997454 | 0.84 | SCN8A (0.56) | SCN8ASCN4AALDH1A1KDM4EMAPK1 | |
| SCHEMBL12727690 | 0.82 | HTR1A (0.49) | SCN8ASCN4ATDP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27516674 | 0.82 | SCN8A (0.53) | SCN8AALDH1A1KDM4ETSHR | |
| SCHEMBL4054602 | 0.81 | L3MBTL1 (0.49) | ALDH1A1KDM4ETDP1CYP1A2CYP3A4 | |
| SCHEMBL258076 | 0.80 | PDCD1 (0.47) | SCN8ASCN4AALDH1A1KDM4ETDP1 | |
| SCHEMBL31392539 | 0.80 | HPGD (0.50) | ALDH1A1KDM4ETDP1CYP1A2CYP3A4 | |
| SCHEMBL3783502 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1CYP1A2CYP3A4 | |
| SCHEMBL29997699 | 0.80 | ALDH1A1 (0.43) | SCN8AALDH1A1KDM4ETDP1CYP1A2 | |
| SCHEMBL27572284 | 0.80 | L3MBTL1 (0.48) | ALDH1A1KDM4ETDP1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |