Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194180 | 0.87 | CYP1A2 (0.59) | LMNANPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL30000594 | 0.87 | LMNA (0.57) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL28596998 | 0.81 | ALDH1A1 (0.58) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL31500051 | 0.80 | NPC1 (0.71) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL30001203 | 0.79 | LMNA (0.53) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL11487535 | 0.77 | LMNA (0.74) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL28694486 | 0.77 | KMT2A (0.44) | LMNANPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL28601785 | 0.76 | ABCG2 (0.53) | LMNARAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL8590861 | 0.75 | KMT2A (0.55) | LMNANPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL11730930 | 0.75 | MEN1 (0.55) | LMNANPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113072501-B | 1-phenyl-3- (pyrazol-4-yl) prop-2-ene-1-one derivative and preparation method and medical application thereof | 武汉科技大学 | 2022-10-14 | — | — | CN | disclosed |