Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5928922 | 0.85 | LMNA (0.70) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL9593922 | 0.82 | LMNA (0.67) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1779819 | 0.80 | HTT (0.64) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL17320200 | 0.79 | LMNA (0.48) | LMNAHTTMAPTMPOSMN1; SMN2 | |
| SCHEMBL8883561 | 0.78 | LMNA (0.60) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL8883850 | 0.78 | LMNA (0.60) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL29956682 | 0.78 | LMNA (0.60) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL1267498 | 0.78 | SMN1; SMN2 (0.66) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL3835167 | 0.78 | HTT (0.64) | LMNAHTTMAPTSMN1; SMN2MEN1 | |
| SCHEMBL30001203 | 0.77 | LMNA (0.53) | LMNAHTTMAPTSMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4226877-A | ANTIPSYCHOTIC AGENTS, SCHIZOPHRENIA | ABBOTT LABORATORIES (US) | 1980-10-07 | — | — | US | disclosed |