SCHEMBL30002219

SCHEMBL30002219

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(OC(=O)N(c5ccccc5)c5ccccc5)nc(NC(=O)C(C)C)nc43)[C@H](O)[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TYMP P19971 14/20 0.56
ADORA1 P30542 2/20 0.42
HINT1 P49773 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1064717 0.91 TYMP (0.59) TYMPADORA1
SCHEMBL14665048 0.91 TYMP (0.59) TYMPADORA1
SCHEMBL29657013 0.91 TYMP (0.46) TYMPADORA1
SCHEMBL9218371 0.89 TYMP (0.44) TYMPADORA1
SCHEMBL26781527 0.88 TYMP (0.44) TYMPADORA1
SCHEMBL30002378 0.86 ADORA2A (0.52) ADORA1
SCHEMBL1081208 0.83 TYMP (0.47) TYMPADORA1
SCHEMBL8610817 0.83 TYMP (0.59) TYMPADORA1
SCHEMBL23827232 0.82 CDK5 (0.37) TYMPADORA1
SCHEMBL20394011 0.82 TYMP (0.38) TYMPADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240262859-A1 CHIMERIC NUCLEIC ACID OLIGOMER INCLUDING PHOSPHOROTHIOATE AND BORANOPHOSPHATE, AND METHOD FOR PRODUCING SAME UNIV TOKYO SCIENCE FOUND (JP) 2024-08-08 US disclosed
EP-4349846-A1 CHIMERIC NUCLEIC ACID OLIGOMER INCLUDING PHOSPHOROTHIOATE AND BORANOPHOSPHATE, AND METHOD FOR PRODUCING SAME TOKYO UNIVERSITY OF SCIENCE FOUNDATION (JP) 2024-04-10 EP disclosed
CN-117412983-A Chimeric nucleic acid oligomer comprising phosphorothioate and borazine phosphate, and method for producing same 学校法人东京理科大学 2024-01-16 CN disclosed
WO-2022255469-A1 CHIMERIC NUCLEIC ACID OLIGOMER INCLUDING PHOSPHOROTHIOATE AND BORANOPHOSPHATE, AND METHOD FOR PRODUCING SAME 学校法人東京理科大学 2022-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240262859-A1 CHIMERIC NUCLEIC ACID OLIGOMER INCLUDING PHOSPHOROTHIOATE AND BORANOPHOSPHATE, AND METHOD FOR PRODUCING SAME RNGTT, NSUN2, MTAP TYMP 17/4885ADORA1 250/4885HINT1 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.