Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.55 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | AR | P10275 | 13/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10540003 | 0.88 | ALDH1A1 (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL9522127 | 0.88 | ALDH1A1 (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL12957782 | 0.83 | ALDH1A1 (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL998403 | 0.82 | ALDH1A1 (0.59) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL15334800 | 0.82 | ALDH1A1 (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL27405526 | 0.82 | ALDH1A1 (0.59) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL4119375 | 0.81 | POLB (0.50) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL1585098 | 0.81 | AR (0.52) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL4696500 | 0.78 | ALDH1A1 (0.55) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 | |
| SCHEMBL10492915 | 0.78 | ALDH1A1 (0.39) | ALDH1A1IMPDH2IMPDH1KDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184771-A1 | Bicyclic Heterocyclic Compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2010-07-22 | — | — | US | disclosed |
| EP-1961754-A1 | BICYCLIC HETEROCYCLIC COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-08-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184771-A1 | Bicyclic Heterocyclic Compound | NR3C2, NR3C1, CRHR1 | ALDH1A1 2365/4885IMPDH2 4062/4885IMPDH1 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.