SCHEMBL3000272

SCHEMBL3000272

NNC(=O)c1ccnc(-c2ccccc2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 2/20 0.60
MEN1 O00255 1/20 0.55
KMT2A Q03164 1/20 0.55
KDM4E B2RXH2 5/20 0.51
KDM5C P41229 2/20 0.51
KDM5B Q9UGL1 2/20 0.51
KDM5A P29375 1/20 0.51
ACACB O00763 1/20 0.51
ACACA Q13085 1/20 0.51
ASIC3 Q9UHC3 1/20 0.50
EGFR P00533 1/20 0.50
KDM6B O15054 1/20 0.49
KDM4A O75164 1/20 0.49
KDM4C Q9H3R0 1/20 0.49
KDM2A Q9Y2K7 1/20 0.49
KDM3A Q9Y4C1 1/20 0.49
ALDH1A1 P00352 1/20 0.49
MPO P05164 1/20 0.49
CYP1A2 P05177 1/20 0.49
CYP3A4 P08684 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31418319 0.85 KDM4E (0.64) KAT6AKDM4EKDM4CALDH1A1MPO
SCHEMBL25003812 0.84 MAP4K4 (0.57) KAT6AMEN1KMT2AKDM4EKDM5B
SCHEMBL22444365 0.83 KDM4E (0.70) KDM4EKDM5CKDM5BKDM5AKDM6B
SCHEMBL13702267 0.83 ACACB (0.57) KAT6AKDM4EKDM5CKDM5BKDM5A
SCHEMBL27828455 0.83 CCNC (0.66) KAT6AALDH1A1CCNCCDK8HDAC1
SCHEMBL3711618 0.83 HDAC8 (0.63) KAT6ACCNCCDK8HDAC1KDM1A
SCHEMBL946431 0.81 ASIC3 (0.55) KAT6AKDM4EKDM5CKDM5BASIC3
SCHEMBL29541336 0.81 KDM4C (0.71) KAT6AKDM4EKDM5CKDM5BKDM5A
SCHEMBL648273 0.81 KDM4C (0.71) KAT6AKDM4EKDM5CKDM5BKDM5A
SCHEMBL25003821 0.81 HDAC1 (0.64) MEN1KMT2AKDM4EKDM5BKDM5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023097386-A1 SELECTIVE HDAC6-INHIBITING N-ACYLHYDRAZONE COMPOUNDS, METHODS FOR PRODUCING SAME, COMPOSITIONS, USES, TREATMENT METHODS AND KITS EUROFARMA LABORATÓRIOS S.A (BR) 2023-06-08 WO disclosed
WO-2023097386-A1 SELECTIVE HDAC6-INHIBITING N-ACYLHYDRAZONE COMPOUNDS, METHODS FOR PRODUCING SAME, COMPOSITIONS, USES, TREATMENT METHODS AND KITS EUROFARMA LABORATÓRIOS S.A (BR) 2023-06-08 WO disclosed
US-20100184811-A1 ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS BRIDGE BIORESEARCH RIGHTS (JERSEY) LIMITED (GB) 2010-07-22 US disclosed
EP-2068873-A2 ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS Pharma 2100 (DK) 2009-06-17 EP disclosed
WO-2008031440-A2 ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS PHARMA 2100 (DK) 2008-03-20 WO disclosed
CN-1826335-A Process for producing 1,2, 4-triazole compound and intermediate therefor FUJIYAKUHIN CO LTD (JP) 2006-08-30 CN disclosed
US-20060189811-A1 Process for producing 1,2,4-triazole compound and intermediate therefor FUJIYAKUHIN CO., LTD. (JP) 2006-08-24 US disclosed
EP-1650204-A1 PROCESS FOR PRODUCING 1,2,4-TRIAZOLE COMPOUND AND INTERMEDIATE THEREFOR Fujiyakuhin Co., Ltd. (JP) 2006-04-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100184811-A1 ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS ODC1, OTC, ACACB KAT6A 152/4885MEN1 4193/4885KMT2A 4030/4885
US-20060189811-A1 Process for producing 1,2,4-triazole compound and intermediate therefor CBR3, XDH, CBR1 KAT6A 3684/4885MEN1 2862/4885KMT2A 3624/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.