Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.55 |
| ▸ | KDM5C | P41229 | 2/20 | 0.54 |
| ▸ | KDM4B | O94953 | 1/20 | 0.54 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.54 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KDM6B | O15054 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.53 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.53 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758188 | 0.97 | MAP4K4 (0.57) | ASIC3KDM5CKDM4BKDM5BKAT6A | |
| SCHEMBL1758494 | 0.87 | KDM4C (0.51) | KDM5CKDM4BKDM5BKAT6AKDM4E | |
| SCHEMBL1758360 | 0.86 | PARP10 (0.57) | KDM5CKDM4BKDM5BMAP4K4CHEK2 | |
| SCHEMBL1592852 | 0.86 | KDM4B (0.58) | KDM5CKDM4BKDM5BKDM6BKDM4A | |
| SCHEMBL29541336 | 0.85 | KDM4C (0.71) | ASIC3KDM5CKDM4BKDM5BKAT6A | |
| SCHEMBL648273 | 0.85 | KDM4C (0.71) | ASIC3KDM5CKDM4BKDM5BKAT6A | |
| SCHEMBL30527146 | 0.85 | PIM1 (0.69) | KDM5CKDM4BKDM5BPIM1FYN | |
| SCHEMBL29175671 | 0.85 | PIM1 (0.69) | KDM5CKDM4BKDM5BPIM1FYN | |
| SCHEMBL7038517 | 0.85 | KDM5C (0.69) | KDM5CKDM4BKDM5BKDM4EKDM6B | |
| SCHEMBL29932888 | 0.84 | MAP4K4 (0.55) | KDM5CKDM4BKDM5BKAT6AMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203067-A | Hedgehog pathway modulators | IRM LLC | 2011-09-28 | — | — | CN | claimed |
| US-6605720-B1 | Process for making spirolactone compounds | MERCK & CO., INC. | 2003-08-12 | — | — | US | claimed |
| US-20030144515-A1 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK SHARP & DOHME LLC | 2003-07-31 | — | — | US | claimed |
| US-20250002487-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-01-02 | — | — | US | disclosed |
| CN-111801322-B | Kinase inhibitors for the treatment of central and peripheral nervous system disorders | 迈阿密大学 | 2024-03-15 | — | — | CN | disclosed |
| WO-2023180189-A1 | MPRO TARGETING ANTIVIRAL COMPOUNDS | EXSCIENTIA AI LIMITED (GB) | 2023-09-28 | — | — | WO | disclosed |
| CN-116710453-A | Kinase inhibitors and uses thereof | 璧辰医药技术股份有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-108026056-A | As the 1,3,4- oxadiazole amide derivative compounds of 6 inhibitor of histone deacetylase and the pharmaceutical composition containing it | 株式会社钟根堂 | 2018-05-11 | — | — | CN | disclosed |
| CN-104066718-B | Substituted benzene compounds | EPIZYME股份有限公司 | 2017-08-29 | — | — | CN | disclosed |
| US-20170196844-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2017-07-13 | — | — | US | disclosed |
| US-9586932-B2 | Apoptosis signal-regulating kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20130035339-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC (US) | 2013-02-07 | — | — | US | disclosed |
| US-20130012521-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2013-01-10 | — | — | US | disclosed |
| US-20110009410-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | GILEAD SCIENCES, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| US-20060287378-A1 | Novel pyrroles and imidazoles | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| US-20050239857-A1 | Novel imidazoles | BOLTON GARY L | 2005-10-27 | — | — | US | disclosed |
| EP-1366016-A2 | PROCESS FOR THE PREPARATION OF ARYLETHANOLDIAMINES USEFUL AS AGONISTS OF THE BETA-3-ADRENOCEPTOR | GLAXO GROUP LIMITED (GB) | 2003-12-03 | — | — | EP | disclosed |
| US-6605720-B1 | Process for making spirolactone compounds | MERCK & CO., INC. | 2003-08-12 | — | — | US | disclosed |
| US-20030144515-A1 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | MERCK SHARP & DOHME LLC | 2003-07-31 | — | — | US | disclosed |
| WO-2002066418-A2 | PROCESS FOR THE PREPARATION OF ARYLETHANOLDIAMINES USEFUL AS AGONISTS OF THE BETA-3-ADRENOCEPTOR | GLAXO GROUP LIMITED (GB) | 2002-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030144515-A1 | PROCESS FOR MAKING SPIROLACTONE COMPOUNDS | HSD17B7, PKD1, REN | ASIC3 1372/4885KDM5C 2252/4885KDM4B 2846/4885 |
| US-20170196844-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | BAX, CASP1, CASP6 | ASIC3 2634/4885KDM5C 3134/4885KDM4B 3352/4885 |
| US-20250002487-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | CGAS, TDP1, CYP11B2 | ASIC3 3367/4885KDM5C 4632/4885KDM4B 4499/4885 |
| US-20110009410-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | BAX, CASP1, AIFM1 | ASIC3 2719/4885KDM5C 3035/4885KDM4B 3218/4885 |
| US-20060287378-A1 | Novel pyrroles and imidazoles | PPIP5K2, PPIE, PPOX | ASIC3 3481/4885KDM5C 1310/4885KDM4B 1682/4885 |
| US-20050239857-A1 | Novel imidazoles | HMGCR, HMGB2, HMGB3 | ASIC3 4850/4885KDM5C 549/4885KDM4B 826/4885 |
| US-20130035339-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | BAX, CASP1, MAP3K6 | ASIC3 2363/4885KDM5C 3111/4885KDM4B 3250/4885 |
| US-20130012521-A1 | APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS | BAX, CASP1, CASP6 | ASIC3 2634/4885KDM5C 3134/4885KDM4B 3352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.