SCHEMBL30002731

SCHEMBL30002731

CSc1ccc(C(=O)N[C@H]2CCCC[C@H]2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2NC(=O)NC(C)C)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 20/20 1.00
ADRB2 P07550 1/20 1.00
HRH1 P35367 1/20 1.00
DRD3 P35462 1/20 1.00
GLP1R P43220 1/20 1.00
FFAR4 Q5NUL3 1/20 1.00
GPR119 Q8TDV5 1/20 1.00
CCR3 P51677 2/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3885401 1.00 CCR2 (1.00) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL14896310 1.00 CCR2 (1.00) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3885399 1.00 CCR2 (1.00) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3897177 0.92 CCR2 (0.85) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3888817 0.92 CCR2 (0.85) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3888816 0.92 CCR2 (0.85) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL5947568 0.91 CCR2 (0.84) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3892399 0.91 CCR2 (0.84) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3892402 0.91 CCR2 (0.84) CCR2ADRB2HRH1DRD3GLP1R
SCHEMBL3899694 0.91 CCR2 (0.83) CCR2ADRB2HRH1DRD3GLP1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240197637-A1 POLYMERIC MICROPARTICLES FOR THE LOCAL TREATMENT OF CHRONIC INFLAMMATORY DISEASES FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2024-06-20 US claimed
EP-4322923-A1 POLYMERIC MICROPARTICLES FOR THE LOCAL TREATMENT OF CHRONIC INFLAMMATORY DISEASES Fondazione Istituto Italiano di Tecnologia (IT) 2024-02-21 EP claimed
WO-2022219089-A1 POLYMERIC MICROPARTICLES FOR THE LOCAL TREATMENT OF CHRONIC INFLAMMATORY DISEASES FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2022-10-20 WO claimed
EP-3921420-B1 DRUG DELIVERY COMPOSITIONS FOR OCULAR ADMINISTRATION OF THERAPEUTICS AND METHODS OF USE THEREOF OHIO STATE INNOVATION FOUNDATION (US) 2026-04-08 EP disclosed
US-20260007778-A1 METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES TRANSLATUM MEDICUS INC (CA) 2026-01-08 US disclosed
US-12357564-B2 Methods and compositions for sustained release microparticles for ocular drug delivery OHIO STATE INNOVATION FOUNDATION (US) 2025-07-15 US disclosed
WO-2024178368-A2 THERAPEUTIC PROTEIN COMBINATIONS OHIO STATE INNOVATION FOUNDATION (US) 2024-08-29 WO disclosed
US-20240197637-A1 POLYMERIC MICROPARTICLES FOR THE LOCAL TREATMENT OF CHRONIC INFLAMMATORY DISEASES FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) 2024-06-20 US disclosed
US-20230398063-A1 METHODS AND COMPOSITIONS FOR SUSTAINED RELEASE MICROPARTICLES FOR OCULAR DRUG DELIVERY OHIO STATE INNOVATION FOUNDATION 2023-12-14 US disclosed
WO-2023133560-A2 TISSUE ENGINEERING AND DRUG DELIVERY DEVICE OHIO STATE INNOVATION FOUNDATION (US) 2023-07-13 WO disclosed
WO-2022271255-A1 TISSUE-ENGINEERED SCAFFOLDS AND METHODS OF MAKING GEORGIA TECH RESEARCH CORPORATION (US) 2022-12-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007778-A1 METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES AGER, ALDH1A2, RBP1 CCR2 1297/4885ADRB2 501/4885HRH1 173/4885
US-12357564-B2 Methods and compositions for sustained release microparticles for ocular drug delivery PDE6C, CHMP4B, PDE6D CCR2 4347/4885ADRB2 1717/4885HRH1 3888/4885
US-20230398063-A1 METHODS AND COMPOSITIONS FOR SUSTAINED RELEASE MICROPARTICLES FOR OCULAR DRUG DELIVERY PDE6C, CHMP4B, PDE6D CCR2 4347/4885ADRB2 1717/4885HRH1 3888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.