SCHEMBL30003065

SCHEMBL30003065

C[Si](C)(O[Si](O[Si](O[Si](C)(C)c1ccccc1)(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
NR1H2 P55055 1/20 0.31
NR1H3 Q13133 1/20 0.31
KDM4E B2RXH2 1/20 0.30
CYP3A4 P08684 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29032529 1.00 ESR1 (0.37) ESR1ESR2NR1H2NR1H3KDM4E
SCHEMBL11434022 0.98 ESR1 (0.38) ESR1ESR2NR1H2NR1H3KDM4E
SCHEMBL18179380 0.91 ESR1 (0.34) ESR1ESR2
SCHEMBL30002398 0.87 ESR1 (0.32) ESR1ESR2
SCHEMBL11351724 0.86 ESR1 (0.31) ESR1ESR2
SCHEMBL121414 0.85 ESR1 (0.42) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL16521498 0.83 ESR1 (0.38) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL8992173 0.83 ESR1 (0.38) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL12977053 0.82 LMNA (0.34) ESR1ESR2
SCHEMBL12977031 0.82 ESR1 (0.33) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240247107-A1 CROSS-LINKABLE ORGANOSILOXANE-MODIFIED REACTION RESINS WACKER CHEMIE AG (DE) 2024-07-25 US disclosed
EP-4347702-A1 CROSS-LINKABLE ORGANOSILOXANE-MODIFIED REACTION RESINS Wacker Chemie AG (DE) 2024-04-10 EP disclosed
WO-2022253413-A1 CROSS-LINKABLE ORGANOSILOXANE-MODIFIED REACTION RESINS WACKER CHEMIE AG (DE) 2022-12-08 WO disclosed