SCHEMBL30003357

SCHEMBL30003357

COc1cccnc1C(=O)NCC(=O)OCc1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 5/20 0.58
MEN1 O00255 3/20 0.58
L3MBTL1 Q9Y468 1/20 0.58
SMN1; SMN2 Q16637 1/20 0.49
MAPT P10636 1/20 0.49
RAB9A P51151 1/20 0.49
GAA P10253 1/20 0.47
CTSA P10619 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30004417 0.84 EGLN2 (0.64) KMT2AMEN1L3MBTL1SMN1; SMN2GAA
SCHEMBL8883000 0.83 MEN1 (0.46) KMT2AMEN1L3MBTL1MAPTCTSA
SCHEMBL704947 0.82 EGLN2 (0.64) SMN1; SMN2MAPTGAACTSA
SCHEMBL968780 0.82 KMT2A (0.51) KMT2AMEN1L3MBTL1SMN1; SMN2MAPT
SCHEMBL966224 0.82 KMT2A (0.48) KMT2AMEN1L3MBTL1MAPTRAB9A
SCHEMBL8885345 0.81 PTPN1 (0.48) KMT2AMEN1L3MBTL1
SCHEMBL8883325 0.81 MEN1 (0.50) KMT2AMEN1L3MBTL1MAPTCTSA
Hydrochloric Acid SCHEMBL8882297 0.81 EGLN2 (0.62) SMN1; SMN2MAPTGAACTSA
SCHEMBL8883447 0.80 PTPN1 (0.50) KMT2AMEN1L3MBTL1
SCHEMBL964829 0.80 PTPN1 (0.50) KMT2AMEN1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240182424-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM FIBROGEN, INC. (US) 2024-06-06 US disclosed
US-11680047-B2 Enhanced erythropoiesis and iron metabolism FIBROGEN, INC. (US) 2023-06-20 US disclosed
EP-2298301-B2 MEDICAMENTS FOR TREATING ANEMIA ASSOCIATED WITH KIDNEY DISEASE FIBROGEN INC (US) 2022-11-16 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11680047-B2 Enhanced erythropoiesis and iron metabolism EPOR, HAMP, TFRC KMT2A 1533/4885MEN1 3852/4885L3MBTL1 2062/4885
US-20240182424-A1 ENHANCED ERYTHROPOIESIS AND IRON METABOLISM EPOR, HAMP, TFRC KMT2A 1095/4885MEN1 3714/4885L3MBTL1 1731/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.