Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515598 | 0.81 | MAP4K4 (0.37) | HRH3SLC6A2ACKR3IRAK4KCNH2 | |
| SCHEMBL16160608 | 0.81 | MAP4K4 (0.37) | HRH3SLC6A2ACKR3IRAK4KCNH2 | |
| SCHEMBL16160601 | 0.81 | MAP4K4 (0.37) | HRH3SLC6A2ACKR3IRAK4KCNH2 | |
| Hydrochloric Acid SCHEMBL28851422 | 0.79 | OPRK1 (0.38) | PDK1 | |
| Hydrochloric Acid SCHEMBL28851322 | 0.79 | OPRK1 (0.38) | PDK1 | |
| SCHEMBL18884697 | 0.77 | SMN1; SMN2 (0.46) | HRH3CCR2KCNH2DRD3GRN | |
| SCHEMBL19884735 | 0.75 | HRH3 (0.51) | HRH3SLC6A2CCR2KCNH2 | |
| SCHEMBL30856536 | 0.74 | TDP1 (0.41) | DRD3GRNSORT1GRIN2BPDK1 | |
| SCHEMBL7911375 | 0.73 | IRAK4 (0.39) | HRH3SLC6A2ACKR3IRAK4DRD3 | |
| SCHEMBL23132818 | 0.73 | SLC6A2 (0.42) | HRH3SLC6A2ACKR3CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363665-A1 | QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-11-17 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363665-A1 | QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | SSB, HLA-DRB1, NQO2 | HRH3 5/4885SLC6A2 707/4885ACKR3 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.