Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18884697 | 0.79 | SMN1; SMN2 (0.46) | DRD3PDK1SMN1; SMN2GRIN2BGRN | |
| SCHEMBL5194021 | 0.76 | SIGMAR1 (0.54) | DRD3OPRM1 | |
| SCHEMBL4967943 | 0.75 | GRN (0.42) | TDP1DRD3PDK1GRIN2BGRN | |
| SCHEMBL5192115 | 0.74 | DRD4 (0.48) | SMN1; SMN2KMT2A | |
| SCHEMBL6624384 | 0.74 | GRN (0.39) | DRD3PDK1GRIN2BGRNSORT1 | |
| SCHEMBL26817753 | 0.74 | DRD1 (0.49) | TDP1DRD3PDK1HSD11B1GBA1 | |
| SCHEMBL12233664 | 0.74 | DRD1 (0.49) | TDP1DRD3PDK1HSD11B1GBA1 | |
| SCHEMBL23698678 | 0.74 | PDK1 (0.36) | TDP1DRD3PDK1GRIN2B | |
| SCHEMBL30003724 | 0.74 | HRH3 (0.41) | DRD3PDK1GRIN2BGRNSORT1 | |
| SCHEMBL16160608 | 0.73 | MAP4K4 (0.37) | DRD3PDK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117736134-A | Compounds and methods for enhancing degradation of target proteins and other polypeptides by E3 ubiquitin ligases | 耶鲁大学 | 2024-03-22 | — | — | CN | disclosed |