Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 12/20 | 0.39 |
| ▸ | HTR2C | P28335 | 11/20 | 0.39 |
| ▸ | HTR2A | P28223 | 8/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.36 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27093617 | 1.00 | PARP1 (0.41) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30459676 | 0.83 | PARP1 (0.50) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30695894 | 0.80 | HTR2C (0.49) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30459786 | 0.78 | PARP1 (0.43) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30460068 | 0.78 | HTR2B (0.49) | PARP1HTR2BHTR2CHTR2AHTR3A | |
| SCHEMBL30352141 | 0.76 | PARP1 (0.38) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30351569 | 0.75 | PARP1 (0.38) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30352331 | 0.74 | PARP1 (0.37) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL30936963 | 0.74 | PARP1 (0.45) | PARP1HTR2BHTR2CHTR2AMAPK1 | |
| SCHEMBL28625341 | 0.74 | PARP1 (0.40) | PARP1HTR2BHTR2CHTR2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |