SCHEMBL30005495

SCHEMBL30005495

C[Si]1(C)c2cc(Cl)ccc2Cc2ccc(Cl)cc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AHR P35869 3/20 0.37
CMA1 P23946 2/20 0.37
HTR2A P28223 6/20 0.36
HTR2C P28335 6/20 0.36
HTR2B P41595 4/20 0.36
METAP1 P53582 1/20 0.36
PNMT P11086 1/20 0.34
KDM1A O60341 1/20 0.34
ADRB1 P08588 1/20 0.33
HTR1A P08908 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33
CNR1 P21554 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
HRH1 P35367 1/20 0.33
KCNH2 Q12809 1/20 0.33
PGR P06401 1/20 0.33
DRD2 P14416 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16865798 0.74 DRD1 (0.46) DRD2DRD4
SCHEMBL22174669 0.71 TP53 (0.33) AHRCMA1TP53F7F3
SCHEMBL16263281 0.71 ALDH1A1 (0.39) HTR2AHTR1ATP53
SCHEMBL6904514 0.71 HTR2A (0.50) AHRCMA1HTR2AHTR2CHTR2B
SCHEMBL29572171 0.69 METAP1 (0.57) AHRCMA1HTR2AHTR2CHTR2B
SCHEMBL29581704 0.69 METAP1 (0.47) AHRCMA1HTR2AHTR2CHTR2B
Ammonia Solution, Strong SCHEMBL1325642 0.69
SCHEMBL1922789 0.69 METAP1 (0.57) AHRCMA1HTR2AHTR2CHTR2B
Bromide SCHEMBL189011 0.69
SCHEMBL4896509 0.69 METAP1 (0.47) AHRCMA1HTR2AHTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4337221-A1 SILICONE-BASED DYES AND METHODS FOR MAKING AND USING THE SAME University of Mississippi (US) 2024-03-20 EP disclosed
WO-2022241405-A1 SILICONE-BASED DYES AND METHODS FOR MAKING AND USING THE SAME UNIVERSITY OF MISSISSIPPI (US) 2022-11-17 WO disclosed