SCHEMBL16263281

SCHEMBL16263281

CN(C)c1ccc2c(c1)[Si](C)(C)c1cc(N(C)C)ccc1C2

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
TSHR P16473 4/20 0.39
ALOX15 P16050 2/20 0.39
HSD17B10 Q99714 1/20 0.39
APP P05067 2/20 0.36
TERT O14746 1/20 0.36
MAPT P10636 2/20 0.32
KDM4E B2RXH2 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
CYP3A4 P08684 2/20 0.32
MAPK1 P28482 2/20 0.32
TDP1 Q9NUW8 2/20 0.32
TP53 P04637 1/20 0.32
CHRM5 P08912 1/20 0.32
CHKA P35790 1/20 0.32
MAOA P21397 3/20 0.31
MAOB P27338 3/20 0.31
ABCB1 P08183 1/20 0.31
HTR1A P08908 1/20 0.31
HTR2A P28223 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19886351 0.87
SCHEMBL18503816 0.84 CRHR1 (0.36) HSD17B10CYP3A4
SCHEMBL19886350 0.83 DHFR (0.33)
SCHEMBL23753233 0.79 ALDH1A1 (0.34) ALDH1A1TSHRALOX15HSD17B10APP
SCHEMBL21208418 0.79 TERT (0.42) ALDH1A1TSHRALOX15HSD17B10TERT
SCHEMBL23753279 0.78 ALDH1A1 (0.33) ALDH1A1TSHRALOX15HSD17B10APP
SCHEMBL18503798 0.77 DHFR (0.34) CYP3A4
SCHEMBL15832856 0.76 ALDH1A1 (0.48) ALDH1A1TSHRALOX15HSD17B10APP
SCHEMBL4886295 0.74 ALDH1A1 (0.46) ALDH1A1TSHRALOX15HSD17B10APP
SCHEMBL4886479 0.74 ALDH1A1 (0.46) ALDH1A1TSHRALOX15HSD17B10APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210101915-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2021-04-08 US disclosed
EP-3357928-B1 NOVEL DYES WITH PHOSPHINIC ACID, PHOSPHINATE, PHOSPHONATE AND PHOSPHONAMIDATE SUBSTITUENTS AS AUXOCHROMIC GROUPS AND METHODS FOR PREPARING THE SAME MAX PLANCK GESELLSCHAFT (DE) 2021-01-06 EP disclosed
US-10837909-B2 Super-resolution fluorescent imaging probe THE UNIVERSITY OF TOKYO (JP) 2020-11-17 US disclosed
US-20200247831-A1 AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF POSTECH ACADEMY-INDUSTRY FOUNDATION (KR) 2020-08-06 US disclosed
US-10717751-B2 Near-IR glucose sensors PROFUSA, INC. (US) 2020-07-21 US disclosed
US-10564164-B2 Fluorescent probe, singlet oxygen detection agent, and singlet oxygen detection method OSAKA UNIVERSITY (JP) 2020-02-18 US disclosed
US-10174202-B2 Dyes with phosphinic acid, phosphinate, phosphonate and phosphonamidate substituents as auxochromic groups and methods for preparing the same MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (DE) 2019-01-08 US disclosed
US-20180223102-A1 NOVEL DYES WITH PHOSPHINIC ACID, PHOSPHINATE, PHOSPHONATE AND PHOSPHONAMIDATE SUBSTITUENTS AS AUXOCHROMIC GROUPS AND METHODS FOR PREPARING THE SAME MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E. V. (DE) 2018-08-09 US disclosed
EP-3357928-A1 NOVEL DYES WITH PHOSPHINIC ACID, PHOSPHINATE, PHOSPHONATE AND PHOSPHONAMIDATE SUBSTITUENTS AS AUXOCHROMIC GROUPS AND METHODS FOR PREPARING THE SAME Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2018-08-08 EP disclosed
US-20180179233-A1 NEAR-IR GLUCOSE SENSORS PROFUSA, INC. (US) 2018-06-28 US disclosed
US-20160230011-A1 CELL PERMEABLE, FLUORESCENT DYE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2016-08-11 US disclosed
US-20160230011-A1 CELL PERMEABLE, FLUORESCENT DYE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2016-08-11 US disclosed
US-9410958-B2 Alkyne-activated fluorogenic azide compounds and methods of use thereof THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2016-08-09 US disclosed
US-9346957-B2 Cell permeable, fluorescent dye ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) 2016-05-24 US disclosed
US-9346957-B2 Cell permeable, fluorescent dye ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL) (CH) 2016-05-24 US disclosed
US-20150276752-A1 ALKYNE-ACTIVATED FLUOROGENIC AZIDE COMPOUNDS AND METHODS OF USE THEREOF NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2015-10-01 US disclosed
US-20150185209-A1 BIOLOGICALLY ACTIVE COMPLEX AND ITS PREPARATION SOUTHERN ILLINOIS UNIVERSITY CARBONDALE (US) 2015-07-02 US disclosed
US-20150185209-A1 BIOLOGICALLY ACTIVE COMPLEX AND ITS PREPARATION SOUTHERN ILLINOIS UNIVERSITY CARBONDALE (US) 2015-07-02 US disclosed
US-20140349282-A1 Cell Permeable, Fluorescent Dye ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2014-11-27 US disclosed
US-20140349282-A1 Cell Permeable, Fluorescent Dye ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2014-11-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210101915-A1 NEAR-IR GLUCOSE SENSORS IRS1, INSR, SLC2A4 ALDH1A1 3159/4885TSHR 890/4885ALOX15 4710/4885
US-20150185209-A1 BIOLOGICALLY ACTIVE COMPLEX AND ITS PREPARATION PGLS, FOS, SPR ALDH1A1 3411/4885TSHR 321/4885ALOX15 4202/4885
US-20150276752-A1 ALKYNE-ACTIVATED FLUOROGENIC AZIDE COMPOUNDS AND METHODS OF USE THEREOF ALK, DNPEP, ACR ALDH1A1 591/4885TSHR 1468/4885ALOX15 2549/4885
US-10837909-B2 Super-resolution fluorescent imaging probe CBR3, CNKSR1, CBR1 ALDH1A1 1731/4885TSHR 109/4885ALOX15 1894/4885
US-20160230011-A1 CELL PERMEABLE, FLUORESCENT DYE EPCAM, IK, TSPO ALDH1A1 1077/4885TSHR 1306/4885ALOX15 2357/4885
US-10174202-B2 Dyes with phosphinic acid, phosphinate, phosphonate and phosphonamidate substituents as auxochromic groups and methods for preparing the same OXSR1, RER1, CBR3 ALDH1A1 3163/4885TSHR 145/4885ALOX15 1535/4885
US-20200247831-A1 AMINO-SILA-PYRONIN COMPOUND-BASED ONE- OR TWO-PHOTON ABSORPTION FLUORESCENT SUBSTANCE AND USE THEREOF MKI67, SI, SCNN1A ALDH1A1 1341/4885TSHR 4256/4885ALOX15 3670/4885
US-10564164-B2 Fluorescent probe, singlet oxygen detection agent, and singlet oxygen detection method SLCO2A1, SORD, PPOX ALDH1A1 1292/4885TSHR 4370/4885ALOX15 2295/4885
US-20180179233-A1 NEAR-IR GLUCOSE SENSORS IRS1, INSR, SLC2A4 ALDH1A1 3159/4885TSHR 890/4885ALOX15 4710/4885
US-10717751-B2 Near-IR glucose sensors IRS1, G6PD, SLC2A8 ALDH1A1 467/4885TSHR 1218/4885ALOX15 2931/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.