Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 4/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.36 |
| ▸ | METAP2 | P50579 | 4/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16728595 | 1.00 | LPL (0.37) | LPLLIPGIDO1METAP2AXL | |
| SCHEMBL29795157 | 0.77 | IDO1 (0.38) | IDO1METAP2CDK2FLT3CCNA1 | |
| SCHEMBL21583535 | 0.77 | LPL (0.37) | LPLLIPGGSK3AGSK3BEGFR | |
| SCHEMBL1284278 | 0.77 | METAP2 (0.42) | LPLLIPGIDO1METAP2AXL | |
| SCHEMBL30892204 | 0.77 | METAP2 (0.42) | LPLLIPGIDO1METAP2AXL | |
| SCHEMBL21542750 | 0.73 | IDO1 (0.37) | LPLLIPGIDO1METAP2AXL | |
| SCHEMBL29741038 | 0.73 | MAPT (0.45) | LPLLIPGIDO1METAP2CDK2 | |
| SCHEMBL1318307 | 0.73 | MAPT (0.45) | LPLLIPGIDO1METAP2CDK2 | |
| SCHEMBL6691092 | 0.71 | LPL (0.50) | LPLLIPGROCK1 | |
| SCHEMBL25278627 | 0.71 | TRPA1 (0.41) | METAP2AXLROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4090660-A1 | QUINOXALINE DERIVATIVES | Grünenthal GmbH (DE) | 2022-11-23 | — | — | EP | disclosed |