Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LGMN | Q99538 | 1/20 | 0.38 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.37 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | ICMT | O60725 | 1/20 | 0.34 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CFD | P00746 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20757767 | 0.80 | TRPC5 (0.42) | TRPC5SLC16A3SLC16A1NAMPTCREBBP | |
| SCHEMBL31750096 | 0.80 | SMN1; SMN2 (0.43) | — | |
| SCHEMBL31038878 | 0.79 | BPTF (0.40) | TRPC5SLC16A3SLC16A1NAMPTHTT | |
| SCHEMBL29520631 | 0.76 | PARP1 (0.49) | — | |
| SCHEMBL22481545 | 0.76 | TRPC5 (0.41) | TRPC5SLC16A3SLC16A1NAMPTKMO | |
| SCHEMBL17595754 | 0.76 | TRPC5 (0.39) | LGMNTRPC5SLC16A3SLC16A1NAMPT | |
| SCHEMBL6030967 | 0.75 | CMA1 (0.48) | ICMTHTT | |
| SCHEMBL20757990 | 0.73 | GABRA1 (0.43) | LGMNTRPC5SLC16A3SLC16A1NAMPT | |
| SCHEMBL29520867 | 0.71 | DHODH (0.46) | SLC16A3SLC16A1HAO1 | |
| SCHEMBL2585360 | 0.71 | DHODH (0.46) | SLC16A3SLC16A1HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337642-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | Universite Euro-Mediterraneenne de Fes (MA) | 2024-03-20 | — | — | EP | claimed |
| WO-2022240277-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | UNIVERSITE EURO-MEDITERRANEENNE DE FES (MA) | 2022-11-17 | — | — | WO | claimed |
| EP-4337642-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | Universite Euro-Mediterraneenne de Fes (MA) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240277-A1 | ETHACRYNIC ACID DERIVATIVES AS INHIBITORS OF MPRO PROTEASE AND SARS-COV-2 REPLICATION | UNIVERSITE EURO-MEDITERRANEENNE DE FES (MA) | 2022-11-17 | — | — | WO | disclosed |