Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASPH | Q12797 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.41 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.41 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1173916 | 1.00 | ASPH (0.50) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL19645350 | 0.86 | KMT2A (0.55) | ASPHKMT2ATRPV4SIRT6 | |
| SCHEMBL991402 | 0.84 | KDM4E (0.44) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL15351579 | 0.84 | KDM4E (0.44) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL28285878 | 0.82 | ALDH1A1 (0.42) | ASPHKDM4EHCAR2NAPRTALDH1A1 | |
| SCHEMBL24723840 | 0.82 | TRPV4 (0.41) | ASPHALDH1A1KMT2ATRPV4DHODH | |
| SCHEMBL3343051 | 0.79 | KDM4E (0.47) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL30112078 | 0.79 | KDM4E (0.47) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL70035 | 0.79 | KDM4E (0.59) | ASPHKDM4EHCAR2NAPRTKDM8 | |
| SCHEMBL30881480 | 0.79 | KMT2A (0.36) | ASPHKMT2ATRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4423096-A1 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF | Merck Sharp & Dohme LLC (US) | 2024-09-04 | — | — | EP | disclosed |
| WO-2023076218-A1 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-05-04 | — | — | WO | disclosed |
| EP-4076524-A2 | IRAK DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2022-10-26 | — | — | EP | disclosed |