SCHEMBL30007207

SCHEMBL30007207

COC(=O)c1ccnc(-c2ccc(F)cc2)c1F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 1/20 0.55
SLC6A3 Q01959 1/20 0.55
NPC1 O15118 1/20 0.50
CASP3 P42574 1/20 0.50
RAB9A P51151 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
LMNA P02545 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
CYP1A2 P05177 2/20 0.43
TSHR P16473 2/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C19 P33261 1/20 0.43
MAPK13 O15264 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23930092 1.00 SLC6A4 (0.55) SLC6A4SLC6A3NPC1CASP3RAB9A
SCHEMBL5412400 0.85 SLC6A4 (0.59) SLC6A4SLC6A3NPC1CASP3RAB9A
SCHEMBL18076769 0.85 PDK1 (0.45) SLC6A4SLC6A3L3MBTL1MAPTPSMD14
SCHEMBL30969915 0.85 PDK1 (0.45) SLC6A4SLC6A3L3MBTL1MAPTPSMD14
SCHEMBL26791842 0.83 PDE3B (0.41) LMNACYP1A2CYP2C19MAPK13MAPK12
SCHEMBL22245628 0.81 KDM4E (0.56) LMNACA1CA2ALDH1A1KDM4E
SCHEMBL22290171 0.78 LMNA (0.50) SLC6A4SLC6A3NPC1CASP3RAB9A
SCHEMBL23958849 0.78 NPC1 (0.56) SLC6A4SLC6A3NPC1CASP3RAB9A
SCHEMBL16198463 0.77 KDM4E (0.46) SLC6A4SLC6A3NPC1CASP3RAB9A
SCHEMBL23958825 0.77 SMN1; SMN2 (0.51) SLC6A4SLC6A3NPC1CASP3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4731207-A2 INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS Merck Sharp & Dohme LLC (US) 2026-04-29 EP disclosed
WO-2025006293-A2 INHIBITORS OF HUMAN RESPIRATORY SYNCYTIAL VIRUS AND METAPNEUMOVIRUS MERCK SHARP & DOHME LLC (US) 2025-01-02 WO disclosed
CN-115461336-A RSV inhibiting 3-substituted quinoline and cinnoline derivatives 爱尔兰詹森科学公司 2022-12-09 CN disclosed