Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butorphanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 19/20 | 0.83 |
| ▸ | OPRM1 known ✓ | P35372 | 15/20 | 0.83 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butorphanol SCHEMBL41926 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL3354253 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL30136229 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL2727817 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL29359664 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL20904174 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL27701479 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL10031253 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL16311889 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL28094979 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545816-B | Adhesive patch | 久光制药株式会社 | 2023-04-11 | — | — | CN | disclosed |
| CN-110573160-B | Adhesive patch | 久光制药株式会社 | 2022-11-18 | — | — | CN | disclosed |