Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butorphanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 19/20 | 0.83 |
| ▸ | OPRM1 known ✓ | P35372 | 15/20 | 0.83 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butorphanol SCHEMBL30008734 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL3354253 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL30136229 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL2727817 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL29359664 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL20904174 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL27701479 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL10031253 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL16311889 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL28094979 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4041 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12594388-B2 | Device to deliver a predetermined amount of a substance to a natural orifice of the body | APTARGROUP, INC. (US) | 2026-04-07 | — | — | US | claimed |
| US-20250235641-A1 | DEVICE TO DELIVER A PREDETERMINED AMOUNT OF A SUBSTANCE TO A NATURAL ORIFICE OF THE BODY | APTARGROUP INC. (US) | 2025-07-24 | — | — | US | claimed |
| CN-119770423-A | Butofenol tartrate injection and preparation method thereof | 成都苑东生物制药股份有限公司 | 2025-04-08 | — | — | CN | claimed |
| WO-2025062440-A1 | TOPICAL NANO-DISPERSION COMPOSITIONS AND THEIR PREPARATION THEREOF | PULSE PHARMACEUTICALS PVT. LTD (IN) | 2025-03-27 | — | — | WO | claimed |
| CN-119574703-A | Method and system for detecting bubble defects of basin-type insulator, electronic equipment and storage medium | 山东大学 | 2025-03-07 | — | — | CN | claimed |
| US-20250009666-A1 | RAPIDLY DISSOLVING SALT TABLET COMPOSITIONS AND METHODS | TARRATS LUISAM (US) | 2025-01-09 | — | — | US | claimed |
| EP-3357945-B1 | ADHESIVE POLYMER AND MEDICAL ADHESIVE PATCH | TEIKOKU SEIYAKU KK (JP) | 2024-10-30 | — | — | EP | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| CN-115169567-B | Protection method for superconducting Fluxonium qubit coherence | 西安微电子技术研究所 | 2024-08-09 | — | — | CN | claimed |
| CN-117946004-A | Preparation method and application of butorphanol tartrate and intermediate thereof | 福安药业集团重庆博圣制药有限公司 | 2024-04-30 | — | — | CN | claimed |
| WO-1985002542-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1985-06-20 | — | — | WO | claimed |
| US-4486436-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1984-12-04 | — | — | US | claimed |
| EP-0061287-B1 | ANALGESIC POTENTIATION | McNeilab, Inc. (US) | 1984-08-15 | — | — | EP | claimed |
| EP-0114886-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. | SUNSHINE ABRAHAM (US) | 1984-08-08 | — | — | EP | claimed |
| US-4464376-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | RICHARDSON-VICKS, INC. (US) | 1984-08-07 | — | — | US | claimed |
| WO-1984000488-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | RICHARDSON VICKS INC (US) | 1984-02-16 | — | — | WO | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| EP-0061287-A1 | Analgesic potentiation | McNeilab, Inc. (US) | 1982-09-29 | — | — | EP | claimed |
| US-4338324-A | COMBINATION OF ZOMEPIRAC AND BUTORPHANOL | MCNEILAB, INC. (US) | 1982-07-06 | — | — | US | claimed |