Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Butorphanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 19/20 | 0.83 |
| ▸ | OPRM1 known ✓ | P35372 | 15/20 | 0.83 |
| ▸ | OPRD1 | P41143 | 16/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butorphanol SCHEMBL30008734 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL41926 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL30136229 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL2727817 | 1.00 | OPRK1 (0.83) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL29359664 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL20904174 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL27701479 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL10031253 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL16311889 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 | |
| Butorphanol SCHEMBL28094979 | 0.91 | OPRK1 (1.00) | OPRK1OPRD1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557088-B2 | Methods and compositions for treating conditions | NEOPRO LABS, LLC (US) | 2009-07-07 | — | — | US | claimed |
| EP-2015765-A2 | METHODS AMD COMPOSITIONS FOR TREATING CONDITIONS | Neopro Labs, LLC (US) | 2009-01-21 | — | — | EP | claimed |
| US-20070259818-A1 | Methods and Compositions for Treating Conditions | NEOPRO LABS, LLC | 2007-11-08 | — | — | US | claimed |
| WO-2007112453-A2 | METHODS AMD COMPOSITIONS FOR TREATING CONDITIONS | NEOPRO LABS, LLC (US) | 2007-10-04 | — | — | WO | claimed |
| CN-109071414-B | Improved process for the preparation of butorphanol tartrate | 海蔻有限公司 | 2021-11-05 | — | — | CN | disclosed |
| EP-3436425-B1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LTD (IN) | 2021-01-06 | — | — | EP | disclosed |
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | HIKAL LIMITED (IN) | 2020-01-28 | — | — | US | disclosed |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2019-04-18 | — | — | US | disclosed |
| EP-3436425-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | Hikal Limited (IN) | 2019-02-06 | — | — | EP | disclosed |
| WO-2017168444-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | HIKAL LIMITED (IN) | 2017-10-05 | — | — | WO | disclosed |
| US-9226918-B2 | Methods and compositions for treating or preventing narcotic withdrawal symptoms | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-01-05 | — | — | US | disclosed |
| US-20100144754-A1 | Methods and Compositions for Treating or Preventing Narcotic Withdrawal Symptoms | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-06-10 | — | — | US | disclosed |
| WO-2010065930-A1 | METHODS AND COMPOSITIONS FOR TREATING OR PREVENTING NARCOTIC WITHDRAWAL SYMPTOMS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2010-06-10 | — | — | WO | disclosed |
| US-7557088-B2 | Methods and compositions for treating conditions | NEOPRO LABS, LLC (US) | 2009-07-07 | — | — | US | disclosed |
| US-20090069237-A1 | METHODS AND COMPOSITIONS FOR TREATING CONDITIONS | NEOPRO LABS LLC | 2009-03-12 | — | — | US | disclosed |
| WO-2009012472-A2 | METHODS AND COMPOSITIONS FOR TREATING CONDITIONS | NEOPRO LABS, LLC (US) | 2009-01-22 | — | — | WO | disclosed |
| EP-2015765-A2 | METHODS AMD COMPOSITIONS FOR TREATING CONDITIONS | Neopro Labs, LLC (US) | 2009-01-21 | — | — | EP | disclosed |
| US-20070259818-A1 | Methods and Compositions for Treating Conditions | NEOPRO LABS, LLC | 2007-11-08 | — | — | US | disclosed |
| WO-2007112453-A2 | METHODS AMD COMPOSITIONS FOR TREATING CONDITIONS | NEOPRO LABS, LLC (US) | 2007-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544101-B2 | Process for the preparation of butorphanol tartrate | OPRD1, OPRK1, OPRL1 | OPRK1 2/4885OPRM1 4/4885OPRD1 1/4885 |
| US-20190112273-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF BUTORPHANOL TARTRATE | OPRD1, OPRL1, OPRK1 | OPRK1 3/4885OPRM1 6/4885OPRD1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.