Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.37 |
| ▸ | BCL9 | O00512 | 9/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 9/20 | 0.35 |
| ▸ | MGLL | Q99685 | 3/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23122009 | 1.00 | HSD11B1 (0.37) | HSD11B1BCL9CTNNB1MGLLPRKAA2 | |
| Trifluoroacetic Acid SCHEMBL30009822 | 0.95 | HSD11B1 (0.35) | HSD11B1BCL9CTNNB1MGLLPRKAA2 | |
| SCHEMBL23121734 | 0.88 | HSD11B1 (0.38) | HSD11B1BCL9CTNNB1CRBN | |
| SCHEMBL29816896 | 0.88 | MGLL (0.39) | HSD11B1BCL9CTNNB1MGLLTSHR | |
| SCHEMBL23120508 | 0.88 | MGLL (0.39) | HSD11B1BCL9CTNNB1MGLLTSHR | |
| Hydrochloric Acid SCHEMBL23121732 | 0.87 | BCL9 (0.40) | HSD11B1BCL9CTNNB1MGLLTSHR | |
| Hydrochloric Acid SCHEMBL30009287 | 0.87 | BCL9 (0.40) | HSD11B1BCL9CTNNB1MGLLTSHR | |
| SCHEMBL23123147 | 0.86 | HSD11B1 (0.37) | HSD11B1MGLLTSHRDDB1CRBN | |
| SCHEMBL23121109 | 0.85 | MGLL (0.40) | HSD11B1MGLLTSHRDDB1CRBN | |
| SCHEMBL23121717 | 0.84 | DDB1 (0.40) | HSD11B1BCL9CTNNB1TSHRDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041724-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |