Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | MGLL | Q99685 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23134799 | 0.89 | CRBN (0.36) | HSD11B1DDB1CRBN | |
| SCHEMBL29720863 | 0.89 | CRBN (0.36) | HSD11B1DDB1CRBN | |
| SCHEMBL23121109 | 0.88 | MGLL (0.40) | HSD11B1MGLLTSHRHRH1CCR3 | |
| SCHEMBL23122387 | 0.88 | NR3C1 (0.38) | HSD11B1CRBNNPSR1 | |
| SCHEMBL30008961 | 0.86 | HSD11B1 (0.37) | HSD11B1MGLLTSHRDDB1CRBN | |
| SCHEMBL23122009 | 0.86 | HSD11B1 (0.37) | HSD11B1MGLLTSHRDDB1CRBN | |
| SCHEMBL23123241 | 0.84 | DDB1 (0.40) | HSD11B1MGLLTSHRDDB1CRBN | |
| Trifluoroacetic Acid SCHEMBL30009822 | 0.84 | HSD11B1 (0.35) | HSD11B1MGLLTSHRDDR1 | |
| SCHEMBL31255252 | 0.82 | MAPT (0.43) | HSD11B1MGLLTSHRHRH1CCR3 | |
| SCHEMBL23120508 | 0.82 | MGLL (0.39) | HSD11B1MGLLTSHRHRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114641473-A | BRD9 bifunctional degradation agent and use method thereof | 诺华股份有限公司 | 2022-06-17 | — | — | CN | disclosed |
| WO-2021055295-A1 | BRD9 BIFUNCTIONAL DEGRADERS AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-03-25 | — | — | WO | disclosed |