Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL298453 | 0.76 | AAK1 (0.49) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL297243 | 0.75 | SRC (0.40) | MEN1KMT2AMETALDH1A1MAPT | |
| SCHEMBL15936238 | 0.69 | HTR1A (0.63) | MAOBMAOAHTR1AADRA1DADRA1A | |
| SCHEMBL858758 | 0.69 | LMNA (0.46) | KMT2AALDH1A1MAPTLMNAPKM | |
| SCHEMBL24696857 | 0.69 | MAOB (0.62) | MAOBMAOAHTR1AADRA1DADRA1A | |
| SCHEMBL29871300 | 0.69 | KMT2A (0.51) | MAOBHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL28515689 | 0.69 | KMT2A (0.51) | MAOBHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL12173106 | 0.68 | MAPT (0.71) | MAOBMAOAHTR1AADRA1DADRA1A | |
| SCHEMBL6599866 | 0.68 | MAOB (0.68) | MAOBMAOAMEN1KMT2AALDH1A1 | |
| SCHEMBL300130 | 0.68 | MTNR1A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427433-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | Plexxikon, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129570-A1 | SOLID FORMS OF SULFONAMIDES AND AMINO ACIDS | PLEXXIKON, INC. (US) | 2010-11-11 | — | — | WO | disclosed |