Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS5 | Q9UNA0 | 14/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.49 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.49 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.49 |
| ▸ | FAP | Q12884 | 1/20 | 0.47 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23745404 | 0.92 | ADAMTS5 (0.63) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745212 | 0.85 | ADAMTS5 (0.52) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745408 | 0.83 | ADAMTS5 (0.58) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745222 | 0.83 | ADAMTS5 (0.53) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745421 | 0.82 | ADAMTS5 (0.66) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745344 | 0.82 | ADAMTS5 (0.55) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL30013124 | 0.80 | ADAMTS5 (0.54) | ADAMTS5ADAM17FAPDPP7DPP4 | |
| SCHEMBL23745420 | 0.75 | ADAMTS5 (0.56) | ADAMTS5ADAMTS4ADAM17ADAM10MMP12 | |
| SCHEMBL23745214 | 0.74 | ADAMTS5 (0.55) | ADAMTS5ADAMTS4ADAM17 | |
| SCHEMBL29250257 | 0.74 | ADAMTS5 (0.55) | ADAMTS5ADAMTS4ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4100005-A1 | ADAMTS INHIBITORS, PREPARATION METHODS AND MEDICINAL USES THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2022-12-14 | — | — | EP | disclosed |