Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.46 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.46 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.46 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.46 |
| ▸ | NPC1L1 | Q9UHC9 | 2/20 | 0.45 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.41 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27123730 | 0.80 | GABRD (0.43) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL27152792 | 0.73 | ITGB3 (0.41) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30066211 | 0.72 | HTR3A (0.37) | — | |
| SCHEMBL27138615 | 0.72 | GABRD (0.38) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30816873 | 0.71 | SOS1 (0.41) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30816878 | 0.71 | GABRD (0.42) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30816881 | 0.71 | GABRD (0.42) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30816866 | 0.71 | GABRD (0.40) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL31697840 | 0.71 | GABRD (0.42) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL30015104 | 0.71 | FFAR4 (0.38) | GABRDGABRA1GABRB1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022223034-A1 | SOS1 DEGRADATION AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223033-A1 | SOS1 DEGRADING AGENT AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |
| WO-2022223039-A1 | SOS1 DEGRADER, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 上海领泰生物医药科技有限公司 | 2022-10-27 | — | — | WO | disclosed |