Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21760971 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2TSHRGLAGAATRPV4 | |
| SCHEMBL29134947 | 0.78 | ALPL (0.58) | SMN1; SMN2GLAALPLKMT2A | |
| SCHEMBL30909386 | 0.73 | TRPV4 (0.45) | ACLYTRPV4IDO1ALPL | |
| SCHEMBL30015429 | 0.72 | IDO1 (0.43) | IDO1CA12CA1CA2CA9 | |
| SCHEMBL1790129 | 0.70 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRGLAGAAALOX15 | |
| SCHEMBL30514814 | 0.70 | SMN1; SMN2 (0.65) | SMN1; SMN2TSHRGLAGAAALOX15 | |
| SCHEMBL13211338 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2ACLYTRPV4ALPL | |
| SCHEMBL47015 | 0.69 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRGLAGAATRPV4 | |
| SCHEMBL1137871 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRGLAGAAALOX15 | |
| SCHEMBL7421633 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2TSHRGLAGAAACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |