Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.75 |
| ▸ | MAP2K1 | Q02750 | 7/20 | 0.70 |
| ▸ | RAF1 | P04049 | 2/20 | 0.70 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 5/20 | 0.70 |
| ▸ | EGFR | P00533 | 7/20 | 0.66 |
| ▸ | LCK | P06239 | 2/20 | 0.66 |
| ▸ | RET | P07949 | 2/20 | 0.66 |
| ▸ | MET | P08581 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 2/20 | 0.66 |
| ▸ | LTK | P29376 | 2/20 | 0.66 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.66 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 2/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13529060 | 0.86 | SRC (0.84) | SRCMAP2K1KDREGFRLCK | |
| SCHEMBL800013 | 0.85 | EGFR (0.78) | SRCKDREGFRLCKRET | |
| SCHEMBL28424819 | 0.84 | SRC (0.85) | SRCMAP2K1KDREGFRLCK | |
| SCHEMBL3531151 | 0.83 | SRC (0.86) | SRCMAP2K1KDREGFRLCK | |
| SCHEMBL346145 | 0.82 | MAP2K1 (1.00) | SRCMAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL30018005 | 0.82 | EGFR (0.81) | EGFR | |
| SCHEMBL30016831 | 0.82 | EGFR (0.60) | SRCRAF1KDREGFRLCK | |
| SCHEMBL4447752 | 0.81 | MAP2K1 (0.86) | SRCMAP2K1RAF1MAPK3MAPK1 | |
| SCHEMBL6704281 | 0.81 | EGFR (0.80) | SRCMAP2K1KDREGFRLCK | |
| SCHEMBL6995929 | 0.81 | MAP2K1 (0.85) | SRCMAP2K1RAF1MAPK3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403557-A | Quinoline and quinazoline compounds as fourth-generation EGFR (epidermal growth factor receptor) inhibitor and application thereof | 华东理工大学 | 2022-11-29 | — | — | CN | disclosed |