Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | GPR3 | P46089 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2345378 | 1.00 | PLAU (0.47) | PLAUCYP2A6GPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL19762264 | 0.77 | NPC1 (0.35) | CYP2A6ALDH1A1NPC1RAB9ACYP1A2 | |
| SCHEMBL1446736 | 0.76 | PLAU (0.50) | PLAUGPR3ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL7260889 | 0.76 | PLAU (0.50) | PLAUGPR3ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL639134 | 0.76 | CYP1A2 (0.50) | PLAUCYP2A6GPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL29751039 | 0.76 | PLAU (0.50) | PLAUGPR3ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18980400 | 0.75 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL13945549 | 0.74 | PLAU (0.48) | PLAUGPR3ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL18430900 | 0.74 | PLAU (0.48) | PLAUCYP2A6GPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL12930803 | 0.74 | PLAU (0.50) | PLAUCYP2A6ALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479546-B2 | Antimalarial hexahydropyrimidine analogues | UCB Biopharma SRL | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479546-B2 | Antimalarial hexahydropyrimidine analogues | G6PD, DPYD, DHODH | PLAU 1432/4885CYP2A6 355/4885GPR3 2580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.