SCHEMBL30022976

SCHEMBL30022976

COc1ccc(Cl)c(-c2cccc(Nc3nc(N4CCC[C@H](NC(=O)OC(C)(C)C)C4)ncc3C(N)=O)c2)c1

nearest known ligand 0.77

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CAMK1D Q8IU85 17/20 0.77
▸ BTK Q06187 1/20 0.49
▸ SYK P43405 3/20 0.49
▸ MAP3K7 O43318 1/20 0.49
▸ CSF1R P07333 1/20 0.49
▸ PIM1 P11309 1/20 0.49
▸ MAPK3 P27361 1/20 0.49
▸ MAPK1 P28482 1/20 0.49
▸ BLK P51451 1/20 0.49
▸ RIPK4 P57078 1/20 0.49
▸ CSNK2A1 P68400 1/20 0.49
▸ KCNH2 Q12809 1/20 0.49
▸ MAP2K5 Q13163 1/20 0.49
▸ MAP3K11 Q16584 1/20 0.49
▸ AURKB Q96GD4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24736508 0.87 CAMK1D (1.00) CAMK1DSYKMAP3K7CSF1RPIM1
SCHEMBL30022563 0.85 CAMK1D (0.73) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL30020768 0.83 BTK (0.65) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL30022978 0.83 CAMK1D (0.60) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL30022291 0.83 CAMK1D (0.75) CAMK1DBTK
SCHEMBL23113253 0.83 CAMK1D (0.60) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL23113255 0.83 CAMK1D (0.60) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL30022981 0.82 CAMK1D (0.76) CAMK1DBTKRIPK4KCNH2MAP2K5
SCHEMBL30022450 0.81 CAMK1D (0.73) CAMK1DBTKSYKMAP3K7CSF1R
SCHEMBL28903909 0.81 CAMK1D (0.60) CAMK1DBTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11530193-B2 Kinase inhibitors THE UNIVERSITY OF MANCHESTER (GB) 2022-12-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11530193-B2 Kinase inhibitors CAMKK2, CAMK1, CAMKK1 CAMK1D 5/4885BTK 1532/4885SYK 1729/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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