Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27157300 | 1.00 | KMT2A (0.53) | KMT2AABL1RIN1HDAC4HDAC6 | |
| SCHEMBL30736170 | 0.85 | KMT2A (0.52) | KMT2AABL1RIN1HDAC4HDAC6 | |
| SCHEMBL27157359 | 0.81 | ACKR3 (0.47) | KMT2AHDAC4HDAC6ACKR3USP30 | |
| SCHEMBL27157330 | 0.81 | KMT2A (0.62) | KMT2AABL1RIN1ALDH1A1HPGD | |
| SCHEMBL27157406 | 0.79 | KMT2A (0.46) | KMT2AABL1RIN1HDAC4HDAC6 | |
| SCHEMBL30025353 | 0.79 | KMT2A (0.46) | KMT2AABL1RIN1HDAC4HDAC6 | |
| SCHEMBL27157329 | 0.78 | KMT2A (0.48) | KMT2AABL1RIN1HDAC4HDAC6 | |
| SCHEMBL16652151 | 0.78 | GPR119 (0.41) | ABL1RIN1HDAC4GPR119USP30 | |
| SCHEMBL16632062 | 0.76 | STS (0.51) | KMT2AABL1RIN1HPGDGPR119 | |
| SCHEMBL27157338 | 0.76 | KMT2A (0.50) | KMT2AABL1RIN1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117751114-A | Small molecule modulators of glucocerebrosidase activity and uses thereof | 凡况生化公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-4329880-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | Vanqua Bio, Inc. (US) | 2024-03-06 | — | — | EP | disclosed |
| WO-2022232360-A1 | SMALL MOLECULE MODULATORS OF GLUCOCEREBROSIDASE ACTIVITY AND USES THEREOF | VANQUA BIO, INC. (US) | 2022-11-03 | — | — | WO | disclosed |