Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amiselimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 known ✓ | P21453 | 11/20 | 0.98 |
| ▸ | S1PR3 known ✓ | Q99500 | 7/20 | 0.55 |
| ▸ | S1PR4 known ✓ | O95977 | 5/20 | 0.55 |
| ▸ | S1PR5 known ✓ | Q9H228 | 5/20 | 0.55 |
| ▸ | S1PR2 known ✓ | O95136 | 3/20 | 0.47 |
| ▸ | TNNC1 | P63316 | 6/20 | 0.55 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.55 |
| ▸ | GPR183 | P32249 | 1/20 | 0.55 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.55 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2465803 | 1.00 | S1PR1 (0.98) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL2462139 | 1.00 | S1PR1 (0.98) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Amiselimod SCHEMBL2463915 | 1.00 | S1PR1 (0.98) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| SCHEMBL2468253 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Amiselimod SCHEMBL29691985 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| SCHEMBL12336974 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Amiselimod SCHEMBL2463680 | 0.99 | S1PR1 (1.00) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL2464567 | 0.96 | S1PR1 (0.89) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| Hydrochloric Acid SCHEMBL2468572 | 0.95 | S1PR1 (0.88) | S1PR1S1PR3TNNC1S1PR4S1PR5 | |
| SCHEMBL12336900 | 0.94 | S1PR1 (0.91) | S1PR1S1PR3TNNC1S1PR4S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119405638-A | Pharmaceutical composition | 田边三菱制药株式会社 | 2025-02-11 | — | — | CN | claimed |
| CN-118662488-A | Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome | 田边三菱制药株式会社 | 2024-09-20 | — | — | CN | claimed |
| CN-114980874-B | Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome | 田边三菱制药株式会社 | 2024-08-13 | — | — | CN | claimed |
| CN-115279355-A | Pharmaceutical composition | 田边三菱制药株式会社 | 2022-11-01 | — | — | CN | claimed |
| CN-119405638-A | Pharmaceutical composition | 田边三菱制药株式会社 | 2025-02-11 | — | — | CN | disclosed |
| CN-118662488-A | Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome | 田边三菱制药株式会社 | 2024-09-20 | — | — | CN | disclosed |
| CN-114980874-B | Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome | 田边三菱制药株式会社 | 2024-08-13 | — | — | CN | disclosed |
| CN-115279355-A | Pharmaceutical composition | 田边三菱制药株式会社 | 2022-11-01 | — | — | CN | disclosed |