Amiselimod

Amiselimod

SCHEMBL2463680

CCCCCCCOc1ccc(CCC(N)(CO)CO)cc1C(F)(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

S1PR1S1PR2S1PR3S1PR4S1PR5

The experimentally established mechanism targets of Amiselimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
S1PR1 known ✓ P21453 11/20 1.00
S1PR3 known ✓ Q99500 7/20 0.56
S1PR4 known ✓ O95977 5/20 0.56
S1PR5 known ✓ Q9H228 5/20 0.56
S1PR2 known ✓ O95136 3/20 0.48
TNNC1 P63316 6/20 0.56
SGPL1 O95470 1/20 0.56
GPR183 P32249 1/20 0.56
CERS2 Q96G23 1/20 0.56
SPHK2 Q9NRA0 2/20 0.50
THRA P10827 1/20 0.50
THRB P10828 1/20 0.50
SPHK1 Q9NYA1 1/20 0.50
CYP3A4 P08684 1/20 0.46
CYP2C8 P10632 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12336974 1.00 S1PR1 (1.00) S1PR1S1PR3TNNC1S1PR4S1PR5
SCHEMBL2468253 1.00 S1PR1 (1.00) S1PR1S1PR3TNNC1S1PR4S1PR5
Amiselimod SCHEMBL29691985 1.00 S1PR1 (1.00) S1PR1S1PR3TNNC1S1PR4S1PR5
Hydrochloric Acid SCHEMBL2462139 0.99 S1PR1 (0.98) S1PR1S1PR3TNNC1S1PR4S1PR5
Amiselimod SCHEMBL30029360 0.99 S1PR1 (0.98) S1PR1S1PR3TNNC1S1PR4S1PR5
Amiselimod SCHEMBL2463915 0.99 S1PR1 (0.98) S1PR1S1PR3TNNC1S1PR4S1PR5
Hydrochloric Acid SCHEMBL2465803 0.99 S1PR1 (0.98) S1PR1S1PR3TNNC1S1PR4S1PR5
SCHEMBL12336900 0.95 S1PR1 (0.91) S1PR1S1PR3TNNC1S1PR4S1PR5
Hydrochloric Acid SCHEMBL2464567 0.94 S1PR1 (0.89) S1PR1S1PR3TNNC1S1PR4S1PR5
SCHEMBL12337616 0.94 S1PR1 (0.89) S1PR1S1PR3TNNC1S1PR4S1PR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 480 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4479083-B1 METHODS OF TREATMENT WITH CAR CELLS IN COMBINATION WITH S1P RECEPTOR MODULATORS PRIOTHERA SAS (FR) 2026-04-22 EP claimed
US-12569455-B2 Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome MITSUBISHI TANABE PHARMA CORPORATION (JP) 2026-03-10 US claimed
EP-4701663-A1 PROLYL HYDROXYLASE DOMAIN-CONTAINING PROTEIN (PHD) INHIBITORS, COMBINATIONS AND USES THEREOF Insilico Medicine IP Limited (HK) 2026-03-04 EP claimed
US-12548678-B2 Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus AMPEL BIOSOLUTIONS, LLC (US) 2026-02-10 US claimed
EP-4640714-A2 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST PML Screening, LLC (US) 2025-10-29 EP claimed
EP-4637819-A1 METHODS OF TREATING INFLAMMATORY DISEASES WITH COMBINATION OF TL1A INHIBITORS AND S1PR INHIBITORS Prometheus Biosciences, Inc. (US) 2025-10-29 EP claimed
US-20250325501-A1 A SPHINGOSINE-1-PHOSPHATE RECEPTOR (S1PR) MODULATOR FOR USE IN TREATING A PATIENT SUFFERING FROM ALZHEIMER'S DEMENTIA UNIV OTTO VON GUERICKE MAGDEBURG (DE) 2025-10-23 US claimed
EP-4587005-A1 SIP 1 RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF TYPE 1 IFN MEDIATED DISEASES Viatris Asia Pacific Pte. Ltd. (SG) 2025-07-23 EP claimed
WO-2025109119-A1 METHODS OF TREATMENT WITH MULTISPECIFIC ANTIGEN-BINDING PROTEINS IN COMBINATION WITH S1P RECEPTOR MODULATORS PRIOTHERA SAS (FR) 2025-05-30 WO claimed
US-20250170176-A1 METHODS OF TREATMENT WITH CAR CELLS IN COMBINATION WITH S1P RECEPTOR MODULATORS PRIOTHERA SAS (FR) 2025-05-29 US claimed
US-20220135666-A1 TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR GLAS USA LLC 2022-05-05 US claimed
EP-3819285-A1 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD Mitsubishi Tanabe Pharma Corporation (JP) 2021-05-12 EP claimed
EP-3492448-B1 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD MITSUBISHI TANABE PHARMA CORP (JP) 2021-03-03 EP claimed
US-10752575-B2 4-alkoxy-3-(trifluoromethyl)benzyl alcohol production method MITSUBISHI TANABE PHARMA CORPORATION (JP) 2020-08-25 US claimed
EP-3492448-A1 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD Mitsubishi Tanabe Pharma Corporation (JP) 2019-06-05 EP claimed
US-20190161432-A1 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD MITSUBISHI TANABE PHARMA CORPORATION (JP) 2019-05-30 US claimed
US-8809304-B2 Amine compound and use thereof for medical purposes MITSUBISHI TANABE PHARMA CORPORATION (JP) 2014-08-19 US claimed
EP-1961734-B1 AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES MITSUBISHI TANABE PHARMA CORP (JP) 2011-09-14 EP claimed
US-20090137530-A1 Amine Compound and Use Thereof for Medical Purposes MITSUBISHI TANABE PHARMA CORPORATION (JP) 2009-05-28 US claimed
EP-1961734-A1 AMINE COMPOUND AND USE THEREOF FOR MEDICAL PURPOSES Mitsubishi Tanabe Pharma Corporation (JP) 2008-08-27 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090137530-A1 Amine Compound and Use Thereof for Medical Purposes HRH3, HRH2, HRH4 S1PR1 370/4885S1PR3 369/4885S1PR4 451/4885
US-20190161432-A1 4-ALKOXY-3-(TRIFLUOROMETHYL)BENZYL ALCOHOL PRODUCTION METHOD ADH1C, ADH5, ADH1A S1PR1 2199/4885S1PR3 1402/4885S1PR4 977/4885
US-20250170176-A1 METHODS OF TREATMENT WITH CAR CELLS IN COMBINATION WITH S1P RECEPTOR MODULATORS S1PR1, S1PR5, S1PR4 S1PR1 1/4885S1PR3 5/4885S1PR4 3/4885
US-10752575-B2 4-alkoxy-3-(trifluoromethyl)benzyl alcohol production method ADH1C, ADH5, ADH1A S1PR1 2199/4885S1PR3 1402/4885S1PR4 977/4885
US-20220135666-A1 TREATMENT OF A DISEASE OF THE GASTROINTESTINAL TRACT WITH A S1P MODULATOR S1PR2, S1PR1, S1PR4 S1PR1 2/4885S1PR3 5/4885S1PR4 3/4885
US-12548678-B2 Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus SSB, METTL16, TLR9 S1PR1 1311/4885S1PR3 1995/4885S1PR4 2184/4885
US-12569455-B2 Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome PMP22, LTA, CD69 S1PR1 444/4885S1PR3 848/4885S1PR4 1119/4885
US-20250325501-A1 A SPHINGOSINE-1-PHOSPHATE RECEPTOR (S1PR) MODULATOR FOR USE IN TREATING A PATIENT SUFFERING FROM ALZHEIMER'S DEMENTIA S1PR1, S1PR5, S1PR4 S1PR1 1/4885S1PR3 5/4885S1PR4 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.