Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.41 |
| ▸ | EDNRA | P25101 | 3/20 | 0.39 |
| ▸ | OGA | O60502 | 3/20 | 0.36 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300262 | 0.78 | EDNRA (0.42) | TRPV1EDNRAOGAGALR3RAB9A | |
| SCHEMBL288126 | 0.77 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL299802 | 0.69 | TRPV1 (0.43) | TRPV1EDNRAOGA | |
| SCHEMBL5717640 | 0.62 | PTGS2 (0.59) | EDNRAOGA | |
| SCHEMBL288083 | 0.62 | TRPV1 (0.71) | TRPV1 | |
| SCHEMBL5191011 | 0.61 | MME (0.55) | EDNRA | |
| SCHEMBL108228 | 0.60 | CYP3A4 (0.54) | OGA | |
| SCHEMBL7289763 | 0.60 | EDNRA (0.51) | EDNRARAB9A | |
| SCHEMBL8035766 | 0.60 | PTGS1 (0.59) | OGA | |
| Hydrochloric Acid SCHEMBL15558801 | 0.60 | EDNRA (0.52) | EDNRAOGARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427436-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127855-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2010-11-11 | — | — | WO | disclosed |