Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL300327 | 0.78 | TRPV1 (0.41) | EDNRAOGAGALR3RAB9ATRPV1 | |
| SCHEMBL287916 | 0.76 | TRPV1 (0.56) | GALR3RAB9ATRPV1 | |
| SCHEMBL299802 | 0.72 | TRPV1 (0.43) | EDNRAOGATRPV1 | |
| SCHEMBL5717640 | 0.65 | PTGS2 (0.59) | EDNRAOGAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL15558801 | 0.65 | EDNRA (0.52) | EDNRAMAPK1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5191011 | 0.64 | MME (0.55) | EDNRACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8035766 | 0.63 | PTGS1 (0.59) | MAPK1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7986595 | 0.62 | PTGS1 (0.55) | OGAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL11410387 | 0.62 | PTGS1 (0.58) | MAPK1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL24580941 | 0.62 | PTGS1 (0.58) | MAPK1CYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427436-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2012-03-14 | — | — | EP | claimed |
| WO-2010127855-A1 | SUBSTITUTED AROMATIC CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS | Grünenthal GmbH (DE) | 2010-11-11 | — | — | WO | claimed |