Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002357 | 1.00 | LMNA (0.44) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL29693601 | 0.83 | LMNA (0.46) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL2401968 | 0.83 | LMNA (0.46) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL17298243 | 0.81 | NOS3 (0.38) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL6635851 | 0.81 | LMNA (0.44) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL1565399 | 0.81 | LMNA (0.44) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL29693617 | 0.81 | LMNA (0.44) | LMNAALDH1A1HPGDAPOBEC3GNOS3 | |
| SCHEMBL22246500 | 0.77 | NOS3 (0.35) | LMNAALDH1A1NOS3NOS1NOS2 | |
| SCHEMBL21047969 | 0.77 | LMNA (0.41) | LMNAALDH1A1HPGDAPOBEC3GTERT | |
| SCHEMBL15538252 | 0.77 | LMNA (0.41) | LMNAALDH1A1HPGDAPOBEC3GCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE49931-E1 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-23 | — | — | US | disclosed |
| US-RE49893-E1 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-04-02 | — | — | US | disclosed |
| US-RE49880-E1 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-03-26 | — | — | US | disclosed |
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-13 | — | — | US | disclosed |
| CN-110997670-B | [1,2,4] triazolo [4,3-a ] pyridyl substituted indole compounds | 百时美施贵宝公司 | 2022-11-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11672780-B2 | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds | TLR7, TLR1, TLR5 | LMNA 2619/4885ALDH1A1 1780/4885HPGD 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.