Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.48 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | EIF4E | P06730 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.36 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.36 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.36 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.36 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.36 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.36 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.36 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.36 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32682445 | 0.87 | NLRP3 (0.47) | NLRP3TRPV3KDM4EALDH1A1HPGD | |
| SCHEMBL30042431 | 0.84 | NLRP3 (0.54) | NLRP3TRPV3CFTRALOX5APFEN1 | |
| SCHEMBL30129718 | 0.84 | NLRP3 (0.42) | NLRP3TRPV3ALOX5APFEN1 | |
| SCHEMBL30041215 | 0.80 | NLRP3 (0.48) | NLRP3TRPV3KDM4EALDH1A1CFTR | |
| Hydrochloric Acid SCHEMBL32682444 | 0.79 | NLRP3 (0.47) | NLRP3TRPV3KDM4EALDH1A1CFTR | |
| SCHEMBL30042437 | 0.77 | NLRP3 (0.45) | NLRP3TRPV3KDM4EALDH1A1HSD17B10 | |
| SCHEMBL30129591 | 0.76 | NLRP3 (0.44) | NLRP3TRPV3KDM4EALDH1A1HPGD | |
| SCHEMBL30042640 | 0.76 | NLRP3 (0.62) | NLRP3TRPV3CFTRBRAFKDR | |
| SCHEMBL30041472 | 0.74 | NLRP3 (0.64) | NLRP3 | |
| SCHEMBL30041003 | 0.69 | NLRP3 (0.49) | NLRP3TRPV3BRAFKDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4129986-B1 | SUBSTITUTED PYRIDAZINE COMPOUND | TENVIE THERAPEUTICS INC (US) | 2026-03-11 | — | — | EP | disclosed |
| US-20230107277-A1 | SUBSTITUTED PYRIDAZINE COMPOUND | NICO THERAPEUTICS, INC. | 2023-04-06 | — | — | US | disclosed |
| EP-4129986-A1 | SUBSTITUTED PYRIDAZINE COMPOUND | Astellas Pharma Inc. (JP) | 2023-02-08 | — | — | EP | disclosed |
| CN-115279739-A | Substituted pyridazine compounds | 安斯泰来制药株式会社 | 2022-11-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230107277-A1 | SUBSTITUTED PYRIDAZINE COMPOUND | NLRP3, NLRP1, PYCARD | NLRP3 1/4885TRPV3 406/4885KDM4E 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.