SCHEMBL30041522

SCHEMBL30041522

C=C(c1ccc(Br)cc1)c1ccccn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TLR7 Q9NYK1 2/20 0.57
▸ L3MBTL1 Q9Y468 3/20 0.51
▸ GAA P10253 1/20 0.51
▸ KMT2A Q03164 4/20 0.50
▸ MEN1 O00255 2/20 0.50
▸ MAPT P10636 4/20 0.49
▸ KDM4E B2RXH2 2/20 0.49
▸ CASP3 P42574 1/20 0.49
▸ SENP8 Q96LD8 1/20 0.49
▸ SENP7 Q9BQF6 1/20 0.49
▸ SENP6 Q9GZR1 1/20 0.49
▸ PTGS2 P35354 1/20 0.45
▸ CES2 O00748 1/20 0.44
▸ CES1 P23141 1/20 0.44
▸ NPC1 O15118 4/20 0.43
▸ LMNA P02545 3/20 0.43
▸ RAB9A P51151 3/20 0.43
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ NAPRT Q6XQN6 1/20 0.42
▸ P4HTM Q9NXG6 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23535836 1.00 TLR7 (0.57) TLR7L3MBTL1GAAKMT2AMEN1
SCHEMBL10824241 0.84 KMT2A (0.59) L3MBTL1GAAKMT2AMEN1MAPT
SCHEMBL29289285 0.81 TLR7 (0.58) TLR7L3MBTL1GAAKMT2AMEN1
SCHEMBL28576081 0.81 KMT2A (0.50) L3MBTL1KMT2AMEN1MAPTKDM4E
SCHEMBL1408599 0.80 CES2 (0.58) L3MBTL1GAAKMT2AMAPTKDM4E
SCHEMBL2956362 0.79 CES2 (0.41) TLR7L3MBTL1GAAKMT2AMEN1
SCHEMBL1156133 0.78 KMT2A (0.72) TLR7L3MBTL1GAAKMT2AMEN1
Methyl Alcohol SCHEMBL28478481 0.78 ALDH1A1 (0.58) L3MBTL1GAAKMT2AMAPTKDM4E
SCHEMBL17814199 0.77 TLR7 (0.61) TLR7L3MBTL1KMT2AMEN1MAPT
SCHEMBL29289270 0.77 RAB9A (0.60) L3MBTL1KMT2AMEN1MAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115427035-B ENL/AF9 YEATS inhibitors 洛克菲勒大学 2025-04-22 — — CN disclosed
CN-115427035-A ENL/AF9YEATS inhibitors 洛克菲勒大学 2022-12-02 — — CN disclosed
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