SCHEMBL30044577

SCHEMBL30044577

CC1=CC(c2cccc([N+](=O)[O-])c2)C=C(C)N1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.50
ACHE P22303 1/20 0.50
CACNA1F O60840 5/20 0.49
CACNA1D Q01668 5/20 0.49
CACNA1S Q13698 5/20 0.49
CACNA1C Q13936 5/20 0.49
ADORA3 P0DMS8 1/20 0.49
LMNA P02545 5/20 0.48
KMT2A Q03164 4/20 0.48
ALDH1A1 P00352 3/20 0.48
GAA P10253 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
MEN1 O00255 3/20 0.47
MAPT P10636 3/20 0.47
KDM4E B2RXH2 1/20 0.47
HIF1A Q16665 3/20 0.45
CYP1A2 P05177 2/20 0.45
CYP3A4 P08684 2/20 0.45
CYP2C9 P11712 2/20 0.45
CYP2C19 P33261 2/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7888022 1.00 TSHR (0.50) TSHRACHECACNA1FCACNA1DCACNA1S
Hydrochloric Acid SCHEMBL28628233 0.98 TSHR (0.49) TSHRACHECACNA1FCACNA1DCACNA1S
SCHEMBL7490704 0.88 CACNA1F (0.48) TSHRACHECACNA1FCACNA1DCACNA1S
SCHEMBL10514933 0.84 HIF1A (0.54) TSHRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7416605 0.82 LMNA (0.46) TSHRACHECACNA1FCACNA1DCACNA1S
SCHEMBL7372793 0.81 CACNA1C (0.40) TSHRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7372786 0.81 ALDH1A1 (0.40) TSHRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7372790 0.80 CACNA1C (0.40) TSHRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7420768 0.79 CACNA1F (0.54) TSHRCACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL7420762 0.79 CACNA1F (0.54) TSHRCACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118930478-A Preparation method of nicardipine hydrochloride 江苏慧聚药业股份有限公司 2024-11-12 CN disclosed
EP-4107742-A1 PREDICTING FORMULATION PROPERTIES Bayer Aktiengesellschaft (DE) 2022-12-28 EP disclosed